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Citation
Yurgel, M.E., Masek, P., DiAngelo, J., Keene, A.C. (2015). Genetic dissection of sleep-metabolism interactions in the fruit fly.  J. Comp. Physiol. A, Neuroethol. Sens. Neural. Behav. Physiol. 201(9): 869--877.
FlyBase ID
FBrf0229426
Publication Type
Review
Abstract

Dysregulation of sleep and metabolism has enormous health consequences. Sleep loss is linked to increased appetite and insulin insensitivity, and epidemiological studies link chronic sleep deprivation to obesity-related disorders including type II diabetes and cardiovascular disease. Interactions between sleep and metabolism involve the integration of signaling from brain regions regulating sleep, feeding, and metabolic function. Investigating the relationship between these processes provides a model to address more general questions of how the brain prioritizes homeostatically regulated behaviors. The availability of powerful genetic tools in the fruit fly, Drosophila melanogaster, allows for precise manipulation of neural function in freely behaving animals. There is a strong conservation of genes and neural circuit principles regulating sleep and metabolic function, and genetic screens in fruit flies have been effective in identifying novel regulators of these processes. Here, we review recent findings in the fruit fly that further our understanding of how the brain modulates sleep in accordance with metabolic state.

PubMed ID
PubMed Central ID
PMC4382448 (PMC) (EuropePMC)
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    J. Comp. Physiol. A, Neuroethol. Sens. Neural. Behav. Physiol.
    Title
    Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology
    Publication Year
    2001-
    ISBN/ISSN
    0340-7594 1432-1351
    Data From Reference
    Genes (16)