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Citation
Rabinovich, D., Yaniv, S.P., Alyagor, I., Schuldiner, O. (2016). Nitric Oxide as a Switching Mechanism between Axon Degeneration and Regrowth during Developmental Remodeling.  Cell 164(1-2): 170--182.
FlyBase ID
FBrf0230650
Publication Type
Research paper
Abstract

During development, neurons switch among growth states, such as initial axon outgrowth, axon pruning, and regrowth. By studying the stereotypic remodeling of the Drosophila mushroom body (MB), we found that the heme-binding nuclear receptor E75 is dispensable for initial axon outgrowth of MB γ neurons but is required for their developmental regrowth. Genetic experiments and pharmacological manipulations on ex-vivo-cultured brains indicate that neuronally generated nitric oxide (NO) promotes pruning but inhibits regrowth. We found that high NO levels inhibit the physical interaction between the E75 and UNF nuclear receptors, likely accounting for its repression of regrowth. Additionally, NO synthase (NOS) activity is downregulated at the onset of regrowth, at least partially, by short inhibitory NOS isoforms encoded within the NOS locus, indicating how NO production could be developmentally regulated. Taken together, these results suggest that NO signaling provides a switching mechanism between the degenerative and regenerative states of neuronal remodeling.

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Obtained with permission from Cell Press.
PubMed ID
PubMed Central ID
PMC5086089 (PMC) (EuropePMC)
Related Publication(s)
Note

Neurodevelopment: Regeneration switch is a gas.
Awasaki and Ito, 2016, Nature 531(7593): 182--183 [FBrf0232520]

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    Language of Publication
    English
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    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Cell
    Title
    Cell
    Publication Year
    1974-
    ISBN/ISSN
    0092-8674
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