Open Close
van Giesen, L., Hernandez-Nunez, L., Delasoie-Baranek, S., Colombo, M., Renaud, P., Bruggmann, R., Benton, R., Samuel, A.D., Sprecher, S.G. (2016). Multimodal stimulus coding by a gustatory sensory neuron in Drosophila larvae.  Nat. Commun. 7(): 10687.
FlyBase ID
Publication Type
Research paper

Accurate perception of taste information is crucial for animal survival. In adult Drosophila, gustatory receptor neurons (GRNs) perceive chemical stimuli of one specific gustatory modality associated with a stereotyped behavioural response, such as aversion or attraction. We show that GRNs of Drosophila larvae employ a surprisingly different mode of gustatory information coding. Using a novel method for calcium imaging in the larval gustatory system, we identify a multimodal GRN that responds to chemicals of different taste modalities with opposing valence, such as sweet sucrose and bitter denatonium, reliant on different sensory receptors. This multimodal neuron is essential for bitter compound avoidance, and its artificial activation is sufficient to mediate aversion. However, the neuron is also essential for the integration of taste blends. Our findings support a model for taste coding in larvae, in which distinct receptor proteins mediate different responses within the same, multimodal GRN.

PubMed ID
PubMed Central ID
PMC4753250 (PMC) (EuropePMC)
Related Publication(s)

Erratum: Multimodal stimulus coding by a gustatory sensory neuron in Drosophila larvae.
van Giesen et al., 2016, Nat. Commun. 7: 11028 [FBrf0231259]

Associated Information
Associated Files
Other Information
Secondary IDs
    Language of Publication
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Nat. Commun.
    Nature communications
    Data From Reference