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van Giesen, L., Hernandez-Nunez, L., Delasoie-Baranek, S., Colombo, M., Renaud, P., Bruggmann, R., Benton, R., Samuel, A.D., Sprecher, S.G. (2016). Multimodal stimulus coding by a gustatory sensory neuron in Drosophila larvae.  Nat. Commun. 7(): 10687.
FlyBase ID
FBrf0230951
Publication Type
Research paper
Abstract

Accurate perception of taste information is crucial for animal survival. In adult Drosophila, gustatory receptor neurons (GRNs) perceive chemical stimuli of one specific gustatory modality associated with a stereotyped behavioural response, such as aversion or attraction. We show that GRNs of Drosophila larvae employ a surprisingly different mode of gustatory information coding. Using a novel method for calcium imaging in the larval gustatory system, we identify a multimodal GRN that responds to chemicals of different taste modalities with opposing valence, such as sweet sucrose and bitter denatonium, reliant on different sensory receptors. This multimodal neuron is essential for bitter compound avoidance, and its artificial activation is sufficient to mediate aversion. However, the neuron is also essential for the integration of taste blends. Our findings support a model for taste coding in larvae, in which distinct receptor proteins mediate different responses within the same, multimodal GRN.

PubMed ID
PubMed Central ID
PMC4753250 (PMC) (EuropePMC)
Related Publication(s)
Erratum

Erratum: Multimodal stimulus coding by a gustatory sensory neuron in Drosophila larvae.
van Giesen et al., 2016, Nat. Commun. 7: 11028 [FBrf0231259]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Nat. Commun.
    Title
    Nature communications
    ISBN/ISSN
    2041-1723
    Data From Reference