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Citation
Hudry, B., Khadayate, S., Miguel-Aliaga, I. (2016). The sexual identity of adult intestinal stem cells controls organ size and plasticity.  Nature 530(7590): 344--348.
FlyBase ID
FBrf0231009
Publication Type
Research paper
Abstract

Sex differences in physiology and disease susceptibility are commonly attributed to developmental and/or hormonal factors, but there is increasing realization that cell-intrinsic mechanisms play important and persistent roles. Here we use the Drosophila melanogaster intestine to investigate the nature and importance of cellular sex in an adult somatic organ in vivo. We find that the adult intestinal epithelium is a cellular mosaic of different sex differentiation pathways, and displays extensive sex differences in expression of genes with roles in growth and metabolism. Cell-specific reversals of the sexual identity of adult intestinal stem cells uncovers the key role this identity has in controlling organ size, reproductive plasticity and response to genetically induced tumours. Unlike previous examples of sexually dimorphic somatic stem cell activity, the sex differences in intestinal stem cell behaviour arise from intrinsic mechanisms that control cell cycle duration and involve a new doublesex- and fruitless-independent branch of the sex differentiation pathway downstream of transformer. Together, our findings indicate that the plasticity of an adult somatic organ is reversibly controlled by its sexual identity, imparted by a new mechanism that may be active in more tissues than previously recognized.

PubMed ID
PubMed Central ID
PMC4800002 (PMC) (EuropePMC)
Related Publication(s)
Personal communication to FlyBase

Irene Miguel-Aliaga insertions.
Miguel-Aliaga, 2017.2.22, Irene Miguel-Aliaga insertions. [FBrf0235241]

Note

Sexual Dimorphism: How Female Cells Win the Race.
Deng and Jasper, 2016, Curr. Biol. 26(5): R212--R215 [FBrf0231225]

Developmental biology: Females have a lot of guts.
Fear and Oliver, 2016, Nature 530(7590): 289--290 [FBrf0231260]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Nature
    Title
    Nature
    Publication Year
    1869-
    ISBN/ISSN
    0028-0836
    Data From Reference
    Aberrations (4)
    Alleles (87)
    Genes (40)
    Natural transposons (2)
    Insertions (11)
    Experimental Tools (5)
    Transgenic Constructs (67)
    Transcripts (5)