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Citation
Fushiki, A., Zwart, M.F., Kohsaka, H., Fetter, R.D., Cardona, A., Nose, A. (2016). A circuit mechanism for the propagation of waves of muscle contraction in Drosophila.  eLife 5(): e13253.
FlyBase ID
FBrf0231611
Publication Type
Research paper
Abstract

Animals move by adaptively coordinating the sequential activation of muscles. The circuit mechanisms underlying coordinated locomotion are poorly understood. Here, we report on a novel circuit for the propagation of waves of muscle contraction, using the peristaltic locomotion of Drosophila larvae as a model system. We found an intersegmental chain of synaptically connected neurons, alternating excitatory and inhibitory, necessary for wave propagation and active in phase with the wave. The excitatory neurons (A27h) are premotor and necessary only for forward locomotion, and are modulated by stretch receptors and descending inputs. The inhibitory neurons (GDL) are necessary for both forward and backward locomotion, suggestive of different yet coupled central pattern generators, and its inhibition is necessary for wave propagation. The circuit structure and functional imaging indicated that the commands to contract one segment promote the relaxation of the next segment, revealing a mechanism for wave propagation in peristaltic locomotion.

PubMed ID
PubMed Central ID
PMC4829418 (PMC) (EuropePMC)
Related Publication(s)
Note

Crawling towards a map of the brain.
Masullo and Tripodi, 2016, eLife 5: e15438 [FBrf0250858]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    eLife
    Title
    eLife
    ISBN/ISSN
    2050-084X
    Data From Reference