Open Close
Reference
Citation
Braden, C.R., Neufeld, T.P. (2016). Atg1-independent induction of autophagy by the Drosophila Ulk3 homolog, ADUK.  FEBS J. 283(21): 3889--3897.
FlyBase ID
FBrf0234023
Publication Type
Research paper
Abstract

Although canonical autophagy regulation requires a multi-protein complex centered on the Ser/Thr-kinase Atg1 (mammalian Ulk1/2), alternative signals can induce autophagy independent of Atg1 through unknown mechanisms. Here we identify the Drosophila Ulk3 ortholog, another Drosophila Unc-51-like kinase (ADUK), as an Atg1-independent autophagy inducer. ADUK interacts with Atg1 complex members Atg13 and 200 kDa FAK family kinase-interacting protein, and requires Atg13 but not Atg1 for autophagy induction. Loss of ADUK shortens adult lifespan and reduces the autophagic response to a chemical stressor, dimethyl sulfoxide. However, ADUK is not required for autophagy induction by Atg1-dependent nutrient or developmental cues. Atg1 and ADUK/Ulk3 thus represent alternative catalytic components of a shared autophagy kinase complex.

PubMed ID
PubMed Central ID
PMC5123689 (PMC) (EuropePMC)
Related Publication(s)
Note

Digesting cytotoxic stressors - an unconventional mechanism to induce autophagy.
Langlois and Wollert, 2016, FEBS J. 283(21): 3886--3888 [FBrf0234124]

Associated Information
Comments
Associated Files
Other Information
Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    FEBS J.
    Title
    FEBS Journal
    Publication Year
    2005-
    ISBN/ISSN
    1742-464X
    Data From Reference
    Alleles (11)
    Gene Groups (1)
    Genes (5)
    Physical Interactions (2)
    Natural transposons (1)
    Insertions (3)
    Experimental Tools (2)
    Transgenic Constructs (7)