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King, A.N., Barber, A.F., Smith, A.E., Dreyer, A.P., Sitaraman, D., Nitabach, M.N., Cavanaugh, D.J., Sehgal, A. (2017). A Peptidergic Circuit Links the Circadian Clock to Locomotor Activity.  Curr. Biol. 27(13): 1915--1927.e5.
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Research paper

The mechanisms by which clock neurons in the Drosophila brain confer an ∼24-hr rhythm onto locomotor activity are unclear, but involve the neuropeptide diuretic hormone 44 (DH44), an ortholog of corticotropin-releasing factor. Here we identified DH44 receptor 1 as the relevant receptor for rest:activity rhythms and mapped its site of action to hugin-expressing neurons in the subesophageal zone (SEZ). We traced a circuit that extends from Dh44-expressing neurons in the pars intercerebralis (PI) through hugin+ SEZ neurons to the ventral nerve cord. Hugin neuropeptide, a neuromedin U ortholog, also regulates behavioral rhythms. The DH44 PI-Hugin SEZ circuit controls circadian locomotor activity in a daily cycle but has minimal effect on feeding rhythms, suggesting that the circadian drive to feed can be separated from circadian locomotion. These findings define a linear peptidergic circuit that links the clock to motor outputs to modulate circadian control of locomotor activity.

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PMC5698909 (PMC) (EuropePMC)
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Personal communication to FlyBase

Location data for Dh44-R1[DsRed] deletion.
King and Sehgal, 2017.12.13, Location data for Dh44-R1[DsRed] deletion. [FBrf0237688]

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