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Riedel, F., Galindo, A., Muschalik, N., Munro, S. (2018). The two TRAPP complexes of metazoans have distinct roles and act on different Rab GTPases.  J. Cell Biol. 217(2): 601--617.
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Research paper

Originally identified in yeast, transport protein particle (TRAPP) complexes are Rab GTPase exchange factors that share a core set of subunits. TRAPPs were initially found to act on Ypt1, the yeast orthologue of Rab1, but recent studies have found that yeast TRAPPII can also activate the Rab11 orthologues Ypt31/32. Mammals have two TRAPP complexes, but their role is less clear, and they contain subunits that are not found in the yeast complexes but are essential for cell growth. To investigate TRAPP function in metazoans, we show that Drosophila melanogaster have two TRAPP complexes similar to those in mammals and that both activate Rab1, whereas one, TRAPPII, also activates Rab11. TRAPPII is not essential but becomes so in the absence of the gene parcas that encodes the Drosophila orthologue of the SH3BP5 family of Rab11 guanine nucleotide exchange factors (GEFs). Thus, in metazoans, Rab1 activation requires TRAPP subunits not found in yeast, and Rab11 activation is shared by TRAPPII and an unrelated GEF that is metazoan specific.

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PMC5800803 (PMC) (EuropePMC)
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Personal communication to FlyBase

Location data for brun[105] deletion.
Riedel and Munro, 2018.8.13, Location data for brun[105] deletion. [FBrf0239827]

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    J. Cell Biol.
    Journal of Cell Biology
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