Open Close
Reference
Citation
Saumweber, T., Rohwedder, A., Schleyer, M., Eichler, K., Chen, Y.C., Aso, Y., Cardona, A., Eschbach, C., Kobler, O., Voigt, A., Durairaja, A., Mancini, N., Zlatic, M., Truman, J.W., Thum, A.S., Gerber, B. (2018). Functional architecture of reward learning in mushroom body extrinsic neurons of larval Drosophila.  Nat. Commun. 9(1): 1104.
FlyBase ID
FBrf0238440
Publication Type
Research paper
Abstract

The brain adaptively integrates present sensory input, past experience, and options for future action. The insect mushroom body exemplifies how a central brain structure brings about such integration. Here we use a combination of systematic single-cell labeling, connectomics, transgenic silencing, and activation experiments to study the mushroom body at single-cell resolution, focusing on the behavioral architecture of its input and output neurons (MBINs and MBONs), and of the mushroom body intrinsic APL neuron. Our results reveal the identity and morphology of almost all of these 44 neurons in stage 3 Drosophila larvae. Upon an initial screen, functional analyses focusing on the mushroom body medial lobe uncover sparse and specific functions of its dopaminergic MBINs, its MBONs, and of the GABAergic APL neuron across three behavioral tasks, namely odor preference, taste preference, and associative learning between odor and taste. Our results thus provide a cellular-resolution study case of how brains organize behavior.

PubMed ID
PubMed Central ID
PMC5856778 (PMC) (EuropePMC)
Associated Information
Comments
Associated Files
Other Information
Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Nat. Commun.
    Title
    Nature communications
    ISBN/ISSN
    2041-1723
    Data From Reference
    Alleles (141)
    Genes (6)
    Natural transposons (2)
    Insertions (2)
    Experimental Tools (5)
    Transgenic Constructs (141)
    Transcripts (132)