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Burgos, A., Honjo, K., Ohyama, T., Qian, C.S., Shin, G.J., Gohl, D.M., Silies, M., Tracey, W.D., Zlatic, M., Cardona, A., Grueber, W.B. (2018). Nociceptive interneurons control modular motor pathways to promote escape behavior in Drosophila.  eLife 7(): e26016.
FlyBase ID
FBrf0238464
Publication Type
Research paper
Abstract

Rapid and efficient escape behaviors in response to noxious sensory stimuli are essential for protection and survival. Yet, how noxious stimuli are transformed to coordinated escape behaviors remains poorly understood. In Drosophila larvae, noxious stimuli trigger sequential body bending and corkscrew-like rolling behavior. We identified a population of interneurons in the nerve cord of Drosophila, termed Down-and-Back (DnB) neurons, that are activated by noxious heat, promote nociceptive behavior, and are required for robust escape responses to noxious stimuli. Electron microscopic circuit reconstruction shows that DnBs are targets of nociceptive and mechanosensory neurons, are directly presynaptic to pre-motor circuits, and link indirectly to Goro rolling command-like neurons. DnB activation promotes activity in Goro neurons, and coincident inactivation of Goro neurons prevents the rolling sequence but leaves intact body bending motor responses. Thus, activity from nociceptors to DnB interneurons coordinates modular elements of nociceptive escape behavior.

PubMed ID
PubMed Central ID
PMC5869015 (PMC) (EuropePMC)
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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    eLife
    Title
    eLife
    ISBN/ISSN
    2050-084X
    Data From Reference
    Alleles (26)
    Genes (13)
    Insertions (6)
    Transgenic Constructs (24)
    Transcripts (8)