FB2025_01 , released February 20, 2025
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Citation
Tian, A., Benchabane, H., Ahmed, Y. (2018). Wingless/Wnt Signaling in Intestinal Development, Homeostasis, Regeneration and Tumorigenesis: A Drosophila Perspective.  J. Dev. Biol. 6(2): E8.
FlyBase ID
FBrf0238606
Publication Type
Review
Abstract
In mammals, the Wnt/β-catenin signal transduction pathway regulates intestinal stem cell maintenance and proliferation, whereas Wnt pathway hyperactivation, resulting primarily from the inactivation of the tumor suppressor Adenomatous polyposis coli (APC), triggers the development of the vast majority of colorectal cancers. The Drosophila adult gut has recently emerged as a powerful model to elucidate the mechanisms by which Wingless/Wnt signaling regulates intestinal development, homeostasis, regeneration, and tumorigenesis. Herein, we review recent insights on the roles of Wnt signaling in Drosophila intestinal physiology and pathology.
PubMed ID
PubMed Central ID
PMC6026893 (PMC) (EuropePMC)
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    J. Dev. Biol.
    Title
    Journal of developmental biology
    ISBN/ISSN
    2221-3759
    Data From Reference
    Gene Groups (1)
    Genes (12)
    Human Disease Models (2)