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Citation
Gabilondo, H., Rubio-Ferrera, I., Losada-Pérez, M., Del Saz, D., León, Y., Molina, I., Torroja, L., W Allan, D., Benito-Sipos, J. (2018). Segmentally homologous neurons acquire two different terminal neuropeptidergic fates in the Drosophila nervous system.  PLoS ONE 13(4): e0194281.
FlyBase ID
FBrf0238644
Publication Type
Research paper
Abstract

In this study, we identify the means by which segmentally homologous neurons acquire different neuropeptide fates in Drosophila. Ventral abdominal (Va)-neurons in the A1 segment of the ventral nerve cord express DH31 and AstA neuropeptides (neuropeptidergic fate I) by virtue of Ubx activity, whereas the A2-A4 Va-neurons express the Capa neuropeptide (neuropeptidergic fate II) under the influence of abdA. These different fates are attained through segment-specific programs of neural subtype specification undergone by segmentally homologous neurons. This is an attractive alternative by which Hox genes can shape Drosophila segmental neural architecture (more sophisticated than the previously identified binary "to live" or "not to live" mechanism). These data refine our knowledge of the mechanisms involved in diversifying neuronal identity within the central nervous system.

PubMed ID
PubMed Central ID
PMC5892886 (PMC) (EuropePMC)
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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    PLoS ONE
    Title
    PLoS ONE
    Publication Year
    2006-
    ISBN/ISSN
    1932-6203
    Data From Reference
    Alleles (11)
    Genes (11)
    Natural transposons (1)
    Insertions (1)
    Experimental Tools (1)
    Transgenic Constructs (6)