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Citation
Pu, Y., Palombo, M.M.M., Shen, P. (2018). Contribution of DA Signaling to Appetitive Odor Perception in a Drosophila Model.  Sci. Rep. 8(1): 5978.
FlyBase ID
FBrf0238658
Publication Type
Research paper
Abstract

Understanding cognitive processes that translate chemically diverse olfactory stimuli to specific appetitive drives remains challenging. We have shown that food-related odors arouse impulsive-like feeding of food media that are palatable and readily accessible in well-nourished Drosophila larvae. Here we provide evidence that two assemblies of four dopamine (DA) neurons, one per brain hemisphere, contribute to perceptual processing of the qualitative and quantitative attributes of food scents. These DA neurons receive neural representations of chemically diverse food-related odors, and their combined neuronal activities become increasingly important as the chemical complexity of an appetizing odor stimulus increases. Furthermore, in each assembly of DA neurons, integrated odor signals are transformed to one-dimensional DA outputs that have no intrinsic reward values. Finally, a genetic analysis has revealed a D1-type DA receptor (Dop1R1)-gated mechanism in neuropeptide Y-like neurons that assigns appetitive significance to selected DA outputs. Our findings suggest that fly larvae provide a useful platform for elucidation of molecular and circuit mechanisms underlying cognitive processing of olfactory and possibly other sensory cues.

PubMed ID
PubMed Central ID
PMC5899149 (PMC) (EuropePMC)
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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Sci. Rep.
    Title
    Scientific reports
    ISBN/ISSN
    2045-2322
    Data From Reference
    Alleles (9)
    Genes (6)
    Natural transposons (1)
    Experimental Tools (1)
    Transgenic Constructs (8)