FB2025_01 , released February 20, 2025
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Citation
Humphries, A.C., Mlodzik, M. (2018). From instruction to output: Wnt/PCP signaling in development and cancer.  Curr. Opin. Cell Biol. 51(): 110--116.
FlyBase ID
FBrf0238871
Publication Type
Review
Abstract
Planar cell polarity (PCP) provides positional information to direct tissue patterning and morphogenesis. While much of the molecular detail of the pathway has been delineated in Drosophila, ensuing studies have shown considerable conservation of both the components and mechanisms of signaling in vertebrates. A recognized feature of PCP is the asymmetric localization of components that translates a global directional cue into a polarized downstream output. Here we discuss recent advances in the PCP field, from the organization of these asymmetric complexes to their upstream directional regulation by Wnt ligands. We also discuss the impact of Wnt/PCP signaling in disease and more specifically an emerging role in cancer progression.
PubMed ID
PubMed Central ID
PMC5949250 (PMC) (EuropePMC)
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Curr. Opin. Cell Biol.
    Title
    Current Opinion in Cell Biology
    Publication Year
    1989-
    ISBN/ISSN
    0955-0674
    Data From Reference
    Genes (8)