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Zhai, Z., Boquete, J.P., Lemaitre, B. (2018). Cell-Specific Imd-NF-κB Responses Enable Simultaneous Antibacterial Immunity and Intestinal Epithelial Cell Shedding upon Bacterial Infection.  Immunity 48(5): 897--910.e7.
FlyBase ID
FBrf0238931
Publication Type
Research paper
Abstract

Intestinal infection triggers potent immune responses to combat pathogens and concomitantly drives epithelial renewal to maintain barrier integrity. Current models propose that epithelial renewal is primarily driven by damage caused by reactive oxygen species (ROS). Here we found that in Drosophila, the Imd-NF-κB pathway controlled enterocyte (EC) shedding upon infection, via a mechanism independent of ROS-associated apoptosis. Mechanistically, the Imd pathway synergized with JNK signaling to induce epithelial cell shedding specifically in the context of bacterial infection, requiring also the reduced expression of the transcription factor GATAe. Furthermore, cell-specific NF-κB responses enabled simultaneous production of antimicrobial peptides (AMPs) and epithelial shedding in different EC populations. Thus, the Imd-NF-κB pathway is central to the intestinal antibacterial response by mediating both AMP production and the maintenance of barrier integrity. Considering the similarities between Drosophila Imd signaling and mammalian TNFR pathway, our findings suggest the existence of an evolutionarily conserved genetic program in immunity-induced epithelial shedding.

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Related Publication(s)
Note

When the Gut Gets Tough, the Enterocytes Get Going.
Chen and Ayres, 2018, Immunity 48(5): 837--839 [FBrf0238992]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Immunity
    Title
    Immunity
    Publication Year
    1994-
    ISBN/ISSN
    1074-7613
    Data From Reference
    Alleles (54)
    Genes (19)
    Sequence Features (5)
    Natural transposons (1)
    Insertions (5)
    Experimental Tools (3)
    Transgenic Constructs (44)