Open Close
Reference
Citation
Amcheslavsky, A., Wang, S., Fogarty, C.E., Lindblad, J.L., Fan, Y., Bergmann, A. (2018). Plasma Membrane Localization of Apoptotic Caspases for Non-apoptotic Functions.  Dev. Cell 45(4): 450--464.e3.
FlyBase ID
FBrf0238978
Publication Type
Research paper
Abstract

Caspases are best characterized for their function in apoptosis. However, they also have non-apoptotic functions such as apoptosis-induced proliferation (AiP), where caspases release mitogens for compensatory proliferation independently of their apoptotic role. Here, we report that the unconventional myosin, Myo1D, which is known for its involvement in left/right development, is an important mediator of AiP in Drosophila. Mechanistically, Myo1D translocates the initiator caspase Dronc to the basal side of the plasma membrane of epithelial cells where Dronc promotes the activation of the NADPH-oxidase Duox for reactive oxygen species generation and AiP in a non-apoptotic manner. We propose that the basal side of the plasma membrane constitutes a non-apoptotic compartment for caspases. Finally, Myo1D promotes tumor growth and invasiveness of the neoplastic scrib RasV12 model. Together, we identified a new function of Myo1D for AiP and tumorigenesis, and reveal a mechanism by which cells sequester apoptotic caspases in a non-apoptotic compartment at the plasma membrane.

PubMed ID
PubMed Central ID
PMC5972739 (PMC) (EuropePMC)
Associated Information
Comments
Associated Files
Other Information
Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Dev. Cell
    Title
    Developmental Cell
    Publication Year
    2001-
    ISBN/ISSN
    1534-5807 1878-1551
    Data From Reference
    Alleles (35)
    Genes (16)
    Human Disease Models (2)
    Physical Interactions (3)
    Insertions (1)
    Transgenic Constructs (28)