Open Close
Reference
Citation
Cande, J., Namiki, S., Qiu, J., Korff, W., Card, G.M., Shaevitz, J.W., Stern, D.L., Berman, G.J. (2018). Optogenetic dissection of descending behavioral control in Drosophila.  eLife 7(): e34275.
FlyBase ID
FBrf0239406
Publication Type
Research paper
Abstract

In most animals, the brain makes behavioral decisions that are transmitted by descending neurons to the nerve cord circuitry that produces behaviors. In insects, only a few descending neurons have been associated with specific behaviors. To explore how descending neurons control an insect's movements, we developed a novel method to systematically assay the behavioral effects of activating individual neurons on freely behaving terrestrial D. melanogaster. We calculated a two-dimensional representation of the entire behavior space explored by these flies, and we associated descending neurons with specific behaviors by identifying regions of this space that were visited with increased frequency during optogenetic activation. Applying this approach across a large collection of descending neurons, we found that (1) activation of most of the descending neurons drove stereotyped behaviors, (2) in many cases multiple descending neurons activated similar behaviors, and (3) optogenetically activated behaviors were often dependent on the behavioral state prior to activation.

PubMed ID
PubMed Central ID
PMC6031430 (PMC) (EuropePMC)
Related Publication(s)
Note

Descending neurons: Disentangling the strings that organize behavior.
Louis and Simpson, 2018, eLife 7: e38410 [FBrf0239532]

Associated Information
Comments
Associated Files
Other Information
Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    eLife
    Title
    eLife
    ISBN/ISSN
    2050-084X
    Data From Reference