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Citation
Chin, S.G., Maguire, S.E., Huoviala, P., Jefferis, G.S.X.E., Potter, C.J. (2018). Olfactory Neurons and Brain Centers Directing Oviposition Decisions in Drosophila.  Cell Rep. 24(6): 1667--1678.
FlyBase ID
FBrf0239741
Publication Type
Research paper
Abstract

The sense of smell influences many behaviors, yet how odors are represented in the brain remains unclear. A major challenge to studying olfaction is the lack of methods allowing activation of specific types of olfactory neurons in an ethologically relevant setting. To address this, we developed a genetic method in Drosophila called olfactogenetics in which a narrowly tuned odorant receptor, Or56a, is ectopically expressed in different olfactory neuron types. Stimulation with geosmin (the only known Or56a ligand) in an Or56a mutant background leads to specific activation of only target olfactory neuron types. We used this approach to identify olfactory sensory neurons (OSNs) that directly guide oviposition decisions. We identify 5 OSN-types (Or71a, Or47b, Or49a, Or67b, and Or7a) that, when activated alone, suppress oviposition. Projection neurons partnering with these OSNs share a region of innervation in the lateral horn, suggesting that oviposition site selection might be encoded in this brain region.

PubMed ID
PubMed Central ID
PMC6290906 (PMC) (EuropePMC)
Related Publication(s)
Note

Stop and smell the geosmin.
Neff, 2018, Lab Anim. (NY) 47(10): 270 [FBrf0241645]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Cell Rep.
    Title
    Cell reports
    ISBN/ISSN
    2211-1247
    Data From Reference