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Alpar, L., Bergantiños, C., Johnston, L.A. (2018). Spatially Restricted Regulation of Spätzle/Toll Signaling during Cell Competition.  Dev. Cell 46(6): 706--719.e5.
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Research paper

Cell competition employs comparisons of fitness to selectively eliminate cells sensed as less healthy. In Drosophila, apoptotic elimination of the weaker "loser" cells from growing wing discs is induced by a signaling module consisting of the Toll ligand Spätzle (Spz), several Toll-related receptors, and NF-κB factors. How this module is activated and restricted to competing disc cells is unknown. Here, we use Myc-induced cell competition to demonstrate that loser cell elimination requires local wing disc synthesis of Spz. We identify Spz processing enzyme (SPE) and modular serine protease (ModSP) as activators of Spz-regulated competitive signaling and show that "winner" cells trigger elimination of nearby WT cells by boosting SPE production. Moreover, Spz requires both Toll and Toll-8 to induce apoptosis of wing disc cells. Thus, during cell competition, Spz-mediated signaling is strictly confined to the imaginal disc, allowing errors in tissue fitness to be corrected without compromising organismal physiology.

PubMed ID
PubMed Central ID
PMC6156939 (PMC) (EuropePMC)
Related Publication(s)

Super-Competitors Game the Fitness Sensing System.
Herrera and Bach, 2018, Dev. Cell 46(6): 672--674 [FBrf0240379]

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    Publication Type
    Dev. Cell
    Developmental Cell
    Publication Year
    1534-5807 1878-1551
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    Aberrations (1)
    Alleles (56)
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    Human Disease Models (1)
    Natural transposons (2)
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