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Citation
Yan, C., Wang, F., Peng, Y., Williams, C.R., Jenkins, B., Wildonger, J., Kim, H.J., Perr, J.B., Vaughan, J.C., Kern, M.E., Falvo, M.R., O'Brien, E.T., Superfine, R., Tuthill, J.C., Xiang, Y., Rogers, S.L., Parrish, J.Z. (2018). Microtubule Acetylation Is Required for Mechanosensation in Drosophila.  Cell Rep. 25(4): 1051--1065.e6.
FlyBase ID
FBrf0240422
Publication Type
Research paper
Abstract

At the cellular level, α-tubulin acetylation alters the structure of microtubules to render them mechanically resistant to compressive forces. How this biochemical property of microtubule acetylation relates to mechanosensation remains unknown, although prior studies have shown that microtubule acetylation influences touch perception. Here, we identify the major Drosophila α-tubulin acetylase (dTAT) and show that it plays key roles in several forms of mechanosensation. dTAT is highly expressed in the larval peripheral nervous system (PNS), but it is largely dispensable for neuronal morphogenesis. Mutation of the acetylase gene or the K40 acetylation site in α-tubulin impairs mechanical sensitivity in sensory neurons and behavioral responses to gentle touch, harsh touch, gravity, and vibration stimuli, but not noxious thermal stimulus. Finally, we show that dTAT is required for mechanically induced activation of NOMPC, a microtubule-associated transient receptor potential channel, and functions to maintain integrity of the microtubule cytoskeleton in response to mechanical stimulation.

PubMed ID
PubMed Central ID
PMC6248335 (PMC) (EuropePMC)
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Cell Rep.
    Title
    Cell reports
    ISBN/ISSN
    2211-1247
    Data From Reference