Open Close
Reference
Citation
Weiglein, A., Gerstner, F., Mancini, N., Schleyer, M., Gerber, B. (2019). One-trial learning in larval Drosophila.  Learn. Mem. 26(4): 109--120.
FlyBase ID
FBrf0241854
Publication Type
Research paper
Abstract

Animals of many species are capable of "small data" learning, that is, of learning without repetition. Here we introduce larval Drosophila melanogaster as a relatively simple study case for such one-trial learning. Using odor-food associative conditioning, we first show that a sugar that is both sweet and nutritious (fructose) and sugars that are only sweet (arabinose) or only nutritious (sorbitol) all support appetitive one-trial learning. The same is the case for the optogenetic activation of a subset of dopaminergic neurons innervating the mushroom body, the memory center of the insects. In contrast, no one-trial learning is observed for an amino acid reward (aspartic acid). As regards the aversive domain, one-trial learning is demonstrated for high-concentration sodium chloride, but is not observed for a bitter tastant (quinine). Second, we provide follow-up, parametric analyses of odor-fructose learning. Specifically, we ascertain its dependency on the number and duration of training trials, the requirements for the behavioral expression of one-trial odor-fructose memory, its temporal stability, and the feasibility of one-trial differential conditioning. Our results set the stage for a neurogenetic analysis of one-trial learning and define the requirements for modeling mnemonic processes in the larva.

PubMed ID
PubMed Central ID
PMC6432171 (PMC) (EuropePMC)
Associated Information
Comments
Associated Files
Other Information
Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Learn. Mem.
    Title
    Learning and Memory
    Publication Year
    1994-
    ISBN/ISSN
    1072-0502
    Data From Reference
    Alleles (3)
    Genes (3)
    Transgenic Constructs (3)