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Citation
Kohsaka, H., Zwart, M.F., Fushiki, A., Fetter, R.D., Truman, J.W., Cardona, A., Nose, A. (2019). Regulation of forward and backward locomotion through intersegmental feedback circuits in Drosophila larvae.  Nat. Commun. 10(1): 2654.
FlyBase ID
FBrf0242656
Publication Type
Research paper
Abstract

Animal locomotion requires spatiotemporally coordinated contraction of muscles throughout the body. Here, we investigate how contractions of antagonistic groups of muscles are intersegmentally coordinated during bidirectional crawling of Drosophila larvae. We identify two pairs of higher-order premotor excitatory interneurons present in each abdominal neuromere that intersegmentally provide feedback to the adjacent neuromere during motor propagation. The two feedback neuron pairs are differentially active during either forward or backward locomotion but commonly target a group of premotor interneurons that together provide excitatory inputs to transverse muscles and inhibitory inputs to the antagonistic longitudinal muscles. Inhibition of either feedback neuron pair compromises contraction of transverse muscles in a direction-specific manner. Our results suggest that the intersegmental feedback neurons coordinate contraction of synergistic muscles by acting as delay circuits representing the phase lag between segments. The identified circuit architecture also shows how bidirectional motor networks could be economically embedded in the nervous system.

PubMed ID
PubMed Central ID
PMC6572865 (PMC) (EuropePMC)
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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Nat. Commun.
    Title
    Nature communications
    ISBN/ISSN
    2041-1723
    Data From Reference
    Alleles (25)
    Genes (10)
    Natural transposons (2)
    Insertions (10)
    Experimental Tools (5)
    Transgenic Constructs (27)