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Kyrchanova, O.V., Leman, D.V., Toshchakov, S.V, Utkina, M.V., Tikhonov, M.V., Parshikov, A.F., Maksimenko, O.G., Georgiev, P.G. (2016). Induction of Transcription through the scs Insulator Leads to Abnormal Development of Drosophila melanogaster.  Russ. J. Genet. 52(10): 1007--1014.
FlyBase ID
FBrf0243183
Publication Type
Research paper
Abstract

A regulatory element named scs is one of the first insulators discovered in Drosophila, which was found on the boundary of the hsp70 domain. The 993-bp scs insulator contains two promoters at the ends and two polyadenylation signals located in the same orientation in the central part of the insulator. In the Drosophila transgenic lines, induction of a strong transcription through the scs insulator only in the direction that coincides with the direction of the two polyadenylation sites activity results in multiple phenotypic defects of the Drosophila development and embryonic lethality. A similar effect was not observed upon testing of other known Drosophila insulators.

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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Russ. J. Genet.
    Title
    Russian Journal of Genetics (English translation edition of Genetika)
    Publication Year
    1994-
    ISBN/ISSN
    1022-7954
    Data From Reference
    Genes (4)