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Citation
Liu, C., Meng, Z., Wiggin, T.D., Yu, J., Reed, M.L., Guo, F., Zhang, Y., Rosbash, M., Griffith, L.C. (2019). A Serotonin-Modulated Circuit Controls Sleep Architecture to Regulate Cognitive Function Independent of Total Sleep in Drosophila.  Curr. Biol. 29(21): 3635--3646.e5.
FlyBase ID
FBrf0243942
Publication Type
Research paper
Abstract

Both the structure and the amount of sleep are important for brain function. Entry into deep, restorative stages of sleep is time dependent; short sleep bouts selectively eliminate these states. Fragmentation-induced cognitive dysfunction is a feature of many common human sleep pathologies. Whether sleep structure is normally regulated independent of the amount of sleep is unknown. Here, we show that in Drosophila melanogaster, activation of a subset of serotonergic neurons fragments sleep without major changes in the total amount of sleep, dramatically reducing long episodes that may correspond to deep sleep states. Disruption of sleep structure results in learning deficits that can be rescued by pharmacologically or genetically consolidating sleep. We identify two reciprocally connected sets of ellipsoid body neurons that form the heart of a serotonin-modulated circuit that controls sleep architecture. Taken together, these findings define a circuit essential for controlling the structure of sleep independent of its amount.

PubMed ID
PubMed Central ID
PMC6832866 (PMC) (EuropePMC)
Related Publication(s)
Note

Neuroscience: Sleep Fragmentation Impairs Memory Formation.
Joiner, 2019, Curr. Biol. 29(22): R1181--RR1184 [FBrf0245843]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Curr. Biol.
    Title
    Current Biology
    Publication Year
    1991-
    ISBN/ISSN
    0960-9822
    Data From Reference