FB2025_01 , released February 20, 2025
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Citation
Axelrod, J.D. (2020). Planar cell polarity signaling in the development of left-right asymmetry.  Curr. Opin. Cell Biol. 62(): 61--69.
FlyBase ID
FBrf0244894
Publication Type
Review
Abstract
The planar cell polarity (PCP) signaling pathway, principally understood from work in Drosophila, is now known to contribute to development in a broad swath of the animal kingdom, and its impairment leads to developmental malformations and diseases affecting humans. The 'core' mechanism underlying PCP signaling polarizes sheets of cells, aligning them in a head-to-tail fashion within the sheet. Cells use the resulting directional information to guide a wide variety of processes. One such process is lateralization, the determination of left-right asymmetry that guides the asymmetric morphology and placement of internal organs. Recent evidence extends the idea that PCP signaling underlies the earliest steps in lateralization and that PCP is invoked again during asymmetric morphogenesis of organs including the heart and gut.
PubMed ID
PubMed Central ID
PMC9258637 (PMC) (EuropePMC)
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Curr. Opin. Cell Biol.
    Title
    Current Opinion in Cell Biology
    Publication Year
    1989-
    ISBN/ISSN
    0955-0674
    Data From Reference
    Genes (7)
    Human Disease Models (1)