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Citation
Sherer, L.M., Catudio Garrett, E., Morgan, H.R., Brewer, E.D., Sirrs, L.A., Shearin, H.K., Williams, J.L., McCabe, B.D., Stowers, R.S., Certel, S.J. (2020). Octopamine neuron dependent aggression requires dVGLUT from dual-transmitting neurons.  PLoS Genet. 16(2): e1008609.
FlyBase ID
FBrf0245076
Publication Type
Research paper
Abstract

Neuromodulators such as monoamines are often expressed in neurons that also release at least one fast-acting neurotransmitter. The release of a combination of transmitters provides both "classical" and "modulatory" signals that could produce diverse and/or complementary effects in associated circuits. Here, we establish that the majority of Drosophila octopamine (OA) neurons are also glutamatergic and identify the individual contributions of each neurotransmitter on sex-specific behaviors. Males without OA display low levels of aggression and high levels of inter-male courtship. Males deficient for dVGLUT solely in OA-glutamate neurons (OGNs) also exhibit a reduction in aggression, but without a concurrent increase in inter-male courtship. Within OGNs, a portion of VMAT and dVGLUT puncta differ in localization suggesting spatial differences in OA signaling. Our findings establish a previously undetermined role for dVGLUT in OA neurons and suggests that glutamate uncouples aggression from OA-dependent courtship-related behavior. These results indicate that dual neurotransmission can increase the efficacy of individual neurotransmitters while maintaining unique functions within a multi-functional social behavior neuronal network.

PubMed ID
PubMed Central ID
PMC7059954 (PMC) (EuropePMC)
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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    PLoS Genet.
    Title
    PLoS Genetics
    Publication Year
    2005-
    ISBN/ISSN
    1553-7404 1553-7390
    Data From Reference
    Alleles (27)
    Genes (16)
    Natural transposons (2)
    Insertions (15)
    Experimental Tools (10)
    Transgenic Constructs (19)
    Transcripts (3)