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Citation
Kim, M., Sujkowski, A., Namkoong, S., Gu, B., Cobb, T., Kim, B., Kowalsky, A.H., Cho, C.S., Semple, I., Ro, S.H., Davis, C., Brooks, S.V., Karin, M., Wessells, R.J., Lee, J.H. (2020). Sestrins are evolutionarily conserved mediators of exercise benefits.  Nat. Commun. 11(1): 190.
FlyBase ID
FBrf0245365
Publication Type
Research paper
Abstract

Exercise is among the most effective interventions for age-associated mobility decline and metabolic dysregulation. Although long-term endurance exercise promotes insulin sensitivity and expands respiratory capacity, genetic components and pathways mediating the metabolic benefits of exercise have remained elusive. Here, we show that Sestrins, a family of evolutionarily conserved exercise-inducible proteins, are critical mediators of exercise benefits. In both fly and mouse models, genetic ablation of Sestrins prevents organisms from acquiring metabolic benefits of exercise and improving their endurance through training. Conversely, Sestrin upregulation mimics both molecular and physiological effects of exercise, suggesting that it could be a major effector of exercise metabolism. Among the various targets modulated by Sestrin in response to exercise, AKT and PGC1α are critical for the Sestrin effects in extending endurance. These results indicate that Sestrin is a key integrating factor that drives the benefits of chronic exercise to metabolism and physical endurance.

PubMed ID
PubMed Central ID
PMC6955242 (PMC) (EuropePMC)
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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Nat. Commun.
    Title
    Nature communications
    ISBN/ISSN
    2041-1723
    Data From Reference