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Citation
Funato, H. (2020). Forward genetic approach for behavioral neuroscience using animal models.  Proc. Jpn Acad. B. Phys. & Biol. Sci. 96(1): 10--31.
FlyBase ID
FBrf0245439
Publication Type
Review
Abstract

Forward genetics is a powerful approach to understand the molecular basis of animal behaviors. Fruit flies were the first animal to which this genetic approach was applied systematically and have provided major discoveries on behaviors including sexual, learning, circadian, and sleep-like behaviors. The development of different classes of model organism such as nematodes, zebrafish, and mice has enabled genetic research to be conducted using more-suitable organisms. The unprecedented success of forward genetic approaches was the identification of the transcription-translation negative feedback loop composed of clock genes as a fundamental and conserved mechanism of circadian rhythm. This approach has now expanded to sleep/wakefulness in mice. A conventional strategy such as dominant and recessive screenings can be modified with advances in DNA sequencing and genome editing technologies.

PubMed ID
PubMed Central ID
PMC6974404 (PMC) (EuropePMC)
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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Proc. Jpn Acad. B. Phys. & Biol. Sci.
    Title
    Proceedings of the Japan Academy
    Publication Year
    1977-
    ISBN/ISSN
    0386-2208
    Data From Reference
    Genes (22)