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Citation
Tsatskis, Y., Rosenfeld, R., Pearson, J.D., Boswell, C., Qu, Y., Kim, K., Fabian, L., Mohammad, A., Wang, X., Robson, M.I., Krchma, K., Wu, J., Gonçalves, J., Hodzic, D., Wu, S., Potter, D., Pelletier, L., Dunham, W.H., Gingras, A.C., Sun, Y., Meng, J., Godt, D., Schedl, T., Ciruna, B., Choi, K., Perry, J.R.B., Bremner, R., Schirmer, E.C., Brill, J.A., Jurisicova, A., McNeill, H. (2020). The NEMP family supports metazoan fertility and nuclear envelope stiffness.  Sci. Adv. 6(35): eabb4591.
FlyBase ID
FBrf0246679
Publication Type
Research paper
Abstract

Human genome-wide association studies have linked single-nucleotide polymorphisms (SNPs) in NEMP1 (nuclear envelope membrane protein 1) with early menopause; however, it is unclear whether NEMP1 has any role in fertility. We show that whole-animal loss of NEMP1 homologs in Drosophila, Caenorhabditis elegans, zebrafish, and mice leads to sterility or early loss of fertility. Loss of Nemp leads to nuclear shaping defects, most prominently in the germ line. Biochemical, biophysical, and genetic studies reveal that NEMP proteins support the mechanical stiffness of the germline nuclear envelope via formation of a NEMP-EMERIN complex. These data indicate that the germline nuclear envelope has specialized mechanical properties and that NEMP proteins play essential and conserved roles in fertility.

PubMed ID
PubMed Central ID
PMC7455189 (PMC) (EuropePMC)
Related Publication(s)
Personal communication to FlyBase

Location data for Nemp deletions.
McNeill, 2020.10.29, Location data for Nemp deletions. [FBrf0247116]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Sci. Adv.
    Title
    Science advances
    ISBN/ISSN
    2375-2548
    Data From Reference
    Alleles (15)
    Genes (4)
    Physical Interactions (1)
    Cell Lines (1)
    Natural transposons (1)
    Insertions (6)
    Experimental Tools (1)
    Transgenic Constructs (12)