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Du, G., Qiao, Y., Zhuo, Z., Zhou, J., Li, X., Liu, Z., Li, Y., Chen, H. (2020). Lipoic acid rejuvenates aged intestinal stem cells by preventing age-associated endosome reduction.  EMBO Rep. 21(8): e49583.
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Research paper

The age-associated decline of adult stem cell function is closely related to the decline in tissue function and age-related diseases. However, the underlying mechanisms that ultimately lead to the observed functional decline of stem cells still remain largely unexplored. This study investigated Drosophila midguts and found a continuous downregulation of lipoic acid synthase, which encodes the key enzyme for the endogenous synthesis of alpha-lipoic acid (ALA), upon aging. Importantly, orally administration of ALA significantly reversed the age-associated hyperproliferation of intestinal stem cells (ISCs) and the observed decline of intestinal function, thus extending the lifespan of Drosophila. This study reports that ALA reverses age-associated ISC dysfunction by promoting the activation of the endocytosis-autophagy network, which decreases in aged ISCs. Moreover, this study suggests that ALA may be used as a safe and effective anti-aging compound for the treatment of ISC-dysfunction-related diseases and for the promotion of healthy aging in humans.

PubMed ID
PubMed Central ID
PMC7403706 (PMC) (EuropePMC)
Related Publication(s)

Lipoic acid and autophagy: new insights into stem cell aging.
Zhang and Edgar, 2020, EMBO Rep. 21(8): e51175 [FBrf0247542]

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    Publication Type
    EMBO Rep.
    EMBO Reports
    Publication Year
    1469-221X 1469-3178
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