Open Close
Sareen, P.F., McCurdy, L.Y., Nitabach, M.N. (2021). A neuronal ensemble encoding adaptive choice during sensory conflict in Drosophila.  Nat. Commun. 12(1): 4131.
FlyBase ID
Publication Type
Research paper

Feeding decisions are fundamental to survival, and decision making is often disrupted in disease. Here, we show that neural activity in a small population of neurons projecting to the fan-shaped body higher-order central brain region of Drosophila represents food choice during sensory conflict. We found that food deprived flies made tradeoffs between appetitive and aversive values of food. We identified an upstream neuropeptidergic and dopaminergic network that relays internal state and other decision-relevant information to a specific subset of fan-shaped body neurons. These neurons were strongly inhibited by the taste of the rejected food choice, suggesting that they encode behavioral food choice. Our findings reveal that fan-shaped body taste responses to food choices are determined not only by taste quality, but also by previous experience (including choice outcome) and hunger state, which are integrated in the fan-shaped body to encode the decision before relay to downstream motor circuits for behavioral implementation.

PubMed ID
PubMed Central ID
Associated Information
Associated Files
Other Information
Secondary IDs
    Language of Publication
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Nat. Commun.
    Nature communications
    Data From Reference
    Alleles (36)
    Genes (19)
    Insertions (1)
    Transgenic Constructs (35)