FB2025_01 , released February 20, 2025
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Citation
Koca, Y., Collu, G.M., Mlodzik, M. (2022). Wnt-frizzled planar cell polarity signaling in the regulation of cell motility.  Curr. Topics Dev. Biol. 150(): 255--297.
FlyBase ID
FBrf0253926
Publication Type
Review
Abstract
The molecular complexes underlying planar cell polarity (PCP) were first identified in Drosophila through analysis of mutant phenotypes in the adult cuticle and the orientation of associated polarized protrusions such as wing hairs and sensory bristles. The same molecules are conserved in vertebrates and are required for the localization of polarized protrusions such as primary or sensory cilia and the orientation of hair follicles. Not only is PCP signaling required to align cellular structures across a tissue, it is also required to coordinate movement during embryonic development and adult homeostasis. PCP signaling allows cells to interpret positional cues within a tissue to move in the appropriate direction and to coordinate this movement with their neighbors. In this review we outline the molecular basis of the core Wnt-Frizzled/PCP pathway, and describe how this signaling orchestrates collective motility in Drosophila and vertebrates. Here we cover the paradigms of ommatidial rotation and border cell migration in Drosophila, and convergent extension in vertebrates. The downstream cell biological processes that underlie polarized motility include cytoskeletal reorganization, and adherens junctional and extracellular matrix remodeling. We discuss the contributions of these processes in the respective cell motility contexts. Finally, we address examples of individual cell motility guided by PCP factors during nervous system development and in cancer disease contexts.
PubMed ID
PubMed Central ID
PMC9870057 (PMC) (EuropePMC)
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Curr. Topics Dev. Biol.
    Title
    Current Topics in Developmental Biology
    Publication Year
    1966-
    ISBN/ISSN
    0070-2153
    Data From Reference
    Genes (10)