FB2026_02 , released June 18, 2026
Insertion: Dmel\P{PZ}dpp10638
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General Information
Symbol
Dmel\P{PZ}dpp10638
Species
D. melanogaster
Name
FlyBase ID
FBti0002737
Feature type
transposable_element_insertion_site
Also Known As
Dpp-LacZ, dpp-lacZ10638, dpp-lacZP10638, dpp10638-lacZ, dppZ, dpp10638
Description
Inserted Element
P{PZ}
LINE ID

l(2)10638

Affected gene(s)
dpp, Ecol\lacZ
Viability / fertility
Associated allele(s)
dpp10638, Ecol\lacZdpp-10638
Stock availability
1 publicly available
Genomic Location
Chromosomal Location
2L ( 22F2 )
Sequence Location
2L:2,454,515..2,454,515 [+]
Target / Docking site
Genomic Maps
Member of Large Scale Dataset(s)
Dataset
TI_set_P{PZ}.BDGP
Description

Insertion lines from this collection were assessed for inclusion in the Gene Disruption Project collection.

(Bellen et al., 2004)

A set of mutant stocks derived by insertional mutagenesis using the P-element construct P{PZ}; most lines have a lethal or sterile phenotype. The P{PZ} construct carries a ry[+] visible marker, Ecol\lacZ enhancer trap sequences, and bacterial sequences that allow plasmid rescue.

(Spradling et al., 1999)
Detailed Mapping Data
Chromosome (arm)
Sequence Location
2L:2,454,515..2,454,515 [+]
Orientation
Cytological location (computed by FlyBase)
22F2 (inferred by FlyBase from sequence location)
Cytological location (reported)
22F1-22F4 (in situ hybridization reported)
(BDGP Project Members, 1994-1999)
Insertion into Natural transposon
Comments concerning location
Sequence Data
Flanking sequence
G00760
(FlyBase, 1992-)
Inserted Element
Construct
P{PZ}
Size (Kb)

14.545

Component Allele(s)
l(3)87Df7.2
ry+t7.2
Molecular map
Affected Gene(s)
Insertion may affect gene
dpp
(Xu et al., 2018, Yan et al., 2009, Jiang and Struhl, 1995)
Ecol\lacZ
(Wojcinski et al., 2011, Casali, 2010, Cheng et al., 2010, Ninov et al., 2010, Yan et al., 2010, Yan et al., 2009, Zhang et al., 2009, Cordero et al., 2007, Callejo et al., 2006, Crickmore and Mann, 2006, Crickmore and Mann, 2006, de Navas et al., 2006, Poulton and Deng, 2006, Wehn and Campbell, 2006, Yasunaga et al., 2006, Panakova et al., 2005, Rogulja and Irvine, 2005, Kankel et al., 2004, Kato et al., 2004, Kwon et al., 2004, Ryoo et al., 2004, Torroja et al., 2004, Wilk et al., 2004, Farge, 2003, Xi et al., 2003, Crack et al., 2002, Micchelli et al., 2002, Briscoe et al., 2001, Hasson et al., 2001, Lefers et al., 2001, Methot and Basler, 2001, Reed et al., 2001, Suzanne et al., 2001, Campbell and Tomlinson, 2000, Cavodeassi et al., 2000, Dobens et al., 2000, Methot and Basler, 2000, Miletich and Limbourg-Bouchon, 2000, Tomoyasu et al., 2000, Usui and Simpson, 2000, Wehrli et al., 2000, Agnes et al., 1999, Burke et al., 1999, Campbell and Tomlinson, 1999, Cavodeassi et al., 1999, Gelbart, 1999.7.20, Hepker et al., 1999, Kopp et al., 1999, Methot and Basler, 1999, Chen and Struhl, 1998, Jackle and Janning, 1998.8.10, Schweizer and Basler, 1998, Vosshall, 1998.8.10, Goto and Hayashi, 1997, Hepker et al., 1997, Kopp et al., 1997, Schneider and Spradling, 1997, Struhl et al., 1997, Burke and Basler, 1996, Chen and Struhl, 1996, Forbes et al., 1996, Twombly et al., 1996, Jiang and Struhl, 1995, Zecca et al., 1995)
Variant Molecular Consequences
Phenotypic Data
Expression Data
Reporter Expression
distribution deduced from reporter
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
larval brain | presumptive
(Jackle and Janning, 1998.8.10)
embryonic/larval anterior spiracle
(Jackle and Janning, 1998.8.10)
organism | segmentally repeated
(Jackle and Janning, 1998.8.10)
presumptive embryonic/larval peripheral nervous system | segmentally repeated
(Jackle and Janning, 1998.8.10)
presumptive embryonic/larval central nervous system | restricted
(Jackle and Janning, 1998.8.10)
embryonic stage 11
amnioserosa
(Reed et al., 2001)
embryonic stage 11 -- 14
embryonic leading edge cell
(Reed et al., 2001)
embryonic stage 14
epidermis | lateral
(Reed et al., 2001)
second instar larval stage
peripodial epithelium of wing disc
(Paul et al., 2013)
third instar larval stage
wing disc | restricted
(Schweizer and Basler, 1998)
wing disc | posterior | proximal
(Foronda et al., 2009)
wing disc anterior compartment | restricted
(Cheng et al., 2010)
anterior-posterior compartment boundary of the wing disc
(Roy et al., 2014)
wandering third instar larval stage
imaginal disc | restricted
(Meister and Braun, 1995.10)
prepupal stage P3 -- pupal stage P5
histoblast nest | restricted
(Ninov et al., 2010)
histoblast | subset
(Ninov et al., 2010)
adult stage
anterior-posterior compartment boundary of the wing blade
(Foronda et al., 2009)
axillary cord
(Foronda et al., 2009)
Additional Information
Statement
Reference

dpp reporter is barely expressed in anterior and posterior dorsal nests histoblasts at 4-6h APF and not at all in surrounding LECs. Only a small group of cells in the ventral nest begin to express at this stage. During the onset of histoblast expansion (16-17h APF), dpp-LacZ is expressed in discrete dorsal cells from the anterior dorsal and ventral nest. In addition, dpp reporter is upregulated in most larval epidermal cells surrounding each of the four nests.

(Ninov et al., 2010)

In addtion to expression anterior to and close to the A/P boundary of third instar wing discs, dpp reporter expression is observed in a proximal region of the posterior compartment beginning in the mid-third-instar larval stage. In the adult wing, staining is observed along the A/P border and in the axillary cord but not in the alula.

(Foronda et al., 2009)

dppFBtr0091350:pb-XREcollacZexpression pattern in the wing disc is restricted to a stripe of cells alongthe antrior-posterior compartment boundary.

(Schweizer and Basler, 1998)

In embryo, expression in anterior spiracles and in PNS not certain.

(Jackle and Janning, 1998.8.10)
 
Marker for
amnioserosa
(Reed et al., 2001)
anterior-posterior compartment boundary of the wing disc
(Roy et al., 2014)
embryonic leading edge cell
(Reed et al., 2001)
Reflects expression of
dpp
(Roy et al., 2014, Paul et al., 2013, Ninov et al., 2010, Foronda et al., 2009, Reed et al., 2001, Schweizer and Basler, 1998)
Reporter construct used in assay
Data on Genetic Line
Line ID

l(2)10638

(Gene Disruption Project members, 2001-)
Origin as a multiple insertion line
Progenitor(s) within the Genome
Related Aberration or Balancer
Aberration
Balancer
Stocks (1)
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (25)
Reported As
Symbol Synonym
Dpp-LacZ
(Wehrli et al., 2000, Campbell and Tomlinson, 1999)
Dpp::lacZ
(Li et al., 2013)
P(PZ)dpp10638
(Dahal et al., 2017)
P2379
(Meister and Braun, 1995.10)
PLacZdpp10638
(Ninov et al., 2010)
P{PZ}dpp10638
(Zappia et al., 2020, FlyBase, 1992-)
P{PZ}l(2)1063810638
(FlyBase, 1992-)
P{ry+t7.2=PZ}dpp10638
(FlyBase, 1992-)
dpp-LacZ
(Ahmed-de-Prado et al., 2024, Saad and Hipfner, 2021, Dahal et al., 2017, Maier et al., 2014, Guo et al., 2013, Cheng et al., 2010, Zhang et al., 2009)
dpp-lacZ
(Rust et al., 2020, Takemura et al., 2020, Zappia et al., 2020, Praktiknjo et al., 2018, Xu et al., 2018, Requena et al., 2017, Li et al., 2013, Paul et al., 2013, Peterson and O'Connor, 2013, Pitsouli and Perrimon, 2013, Yan et al., 2009, Grammont, 2007, Crickmore and Mann, 2006, Poulton and Deng, 2006, Wehn and Campbell, 2006, Yasunaga et al., 2006, Ryoo et al., 2004)
dpp-lacZ (10638)
(Farge, 2003)
dpp-lacZ10628
(Casali, 2010)
dpp-lacZ10638
(Takemura et al., 2020, Pitsouli and Perrimon, 2013, Crickmore and Mann, 2006, de Navas et al., 2006, Miletich and Limbourg-Bouchon, 2000)
dpp-lacZP10638
(Wojcinski et al., 2011, Yan et al., 2010, Han et al., 2004, Burke et al., 1999)
dpp-lacZP10638
(Cordero et al., 2007)
dpp-lacZ[10638]
(Rogulja and Irvine, 2005)
dpp10638
(Guo et al., 2013, Peterson and O'Connor, 2013)
dpp10638-LacZ
(Roy et al., 2014)
dpp10638-lacZ
(Requena et al., 2017, Suzanne et al., 2001)
dppP10638
(Yan et al., 2009)
dpplacZ
(Reed et al., 2001)
dppP10638
(Yan et al., 2009)
dppZ
(Saad and Hipfner, 2021, Wojcinski et al., 2011)
dpplacZ
(Panakova et al., 2005)
l(2)10638
(Stultz et al., 2006)
Name Synonyms
Secondary FlyBase IDs
  • FBti0000225
References (99)