FlyBase Recombinant Construct Report: P{Tdc2-GAL4.C}

ScerGAL4^Tdc2.PC drives expression in 44 neurons of the ventral nerve cord. In brain hemispheres labeling is observed in three distinct locations with one neuron located basomedial to the calyx, a cluster of four anterior to the vertical mushroom body lobes and around two cells dorsomedial to the antennal lobe. ScerGAL4^Tdc2.PC is detected in clusters of VM neurons in all three larval gnathal neuromeres and in one cell at the margin of the subesophageal ganglion to the ventral nerve cord. All ScerGAL4^Tdc2.PC-expressing neurons are tyraminergic, whereas labeled cells positioned in the subesophageal ganglion are octopaminergic as well.

(Selcho et al., 2014)

FLP/FRT intersectional strategy shows expression of ScerGAL4^Tdc2.PC in a subset of cell bodies in the posterior part of the thoracico-abdominal ganglion when combined with dsx^KI.FLPG5. On average nine neurons are labeled in females and three in males. In females these project to the spermathecum, the seminal receptacle, the female accessory gland, the uterus and to both the common and lateral oviduct. In males projections lead to the testis, the ejaculatory duct and the male accessory gland. In both male and female expression can also be detected in a motor neuron that innervates abdominal 6 dorsal muscle 133.

(Rezával et al., 2014)

ScerGAL4^Tdc2.PC drives expression in motor neurons that form type II terminal buttons at the neuromuscular junction.

(Koon and Budnik, 2012)

ScerGAL4^Tdc2.PC drives expression in the adult octopaminergic neurons. Positive GRASP (GFP reconstitution across synaptic partners) signals between the mushroom body alpha and beta lobes labelled with EcollexA^L5076 or EcollexA^L5251 and ScerGAL4^Tdc2.PC are observed sporadically in the alpha and beta lobes and in the calyx.

(Zhou et al., 2012)

ScerGAL4^Tdc2.PC drives expression in clusters of neurons in the adult brain and thoracico-abdominal ganglion. Co-localisation with Tbh protein in the brain is observed in the octopaminergic AL2 cluster, in the G3b and 3 ventral clusters (VMI to VMIII). In the thoracico-abdominal ganglion, 37 of the 39 Tbh-positive neurons also express ScerGAL4^Tdc2.PC.

(Schneider et al., 2012)

The octopaminergic neurons VPM1 and VUM labelled with ScerGAL4^Tdc2.PC co-localise with male-specific fru protein (FruM).

(Certel et al., 2010)

Expression of ScerGAL4^Tdc2.PC is in both octopaminergic and tyraminergic neurons.

(Boerner and Duch, 2010)

Expression observed in neurons that innervate the antennal lobes, mushroom body gamma lobes and their spurs, the subesophageal ganglion, the areas surrounding the esophagus, and the mushroom body calyces.

(Yarali and Gerber, 2010)

ScerGAL4^Tdc2.PC drives expression in several clusters of cells in the adult, in a total of 137 cells per hemisphere. These clusters include the octopaminergic neurons VM (27 cells), AL2 (7 cells), VL (2 cells) and ASM (8 cells). In addition, ScerGAL4^Tdc2.PC labels cells around the protocerebral bridge (PB1 cluster, 65 cells), ventral to the protocerebral bridge (PB2 cluster, 2 cells), posterior superior medial protocerebrum (PSM cluster, 5 cells) and at the anterior margin of the antennal lobe (AL1 cluster, 1 cell).

(Busch et al., 2009)

In larva, ScerGAL4^Tdc.PJ drives expression in a few processes that invade the calyx of the mushroom body and in neurites that surround the peduncle.

(Johard et al., 2008)

Expression is seen in discrete unilateral subsets of cells located along the ventral medial line of the brain, as well as in discrete

(Crocker and Sehgal, 2008)

bilateral clusters of cells in the lateral protocerebrum region and surrounding the esophagus cavity.

(Crocker and Sehgal, 2008)

ScerGAL4^Tdc2.PC drives expression in adult thoracic and abdominal neuromeres. Their cell bodies are located at the midline extending bilateral symmetric axons as well as a net of finer processes.

(Brembs et al., 2007)

Marker for

octopaminergic neuron

(Selcho et al., 2014, Busch et al., 2009)

tyraminergic neuron

(Selcho et al., 2014)

Reflects expression of

Tdc2

(Matsuo et al., 2016, Rezával et al., 2014, Selcho et al., 2014, Burke et al., 2012, Koon and Budnik, 2012, Schneider et al., 2012, Zhou et al., 2012, Kahsai and Winther, 2011, Koon et al., 2011, Boerner and Duch, 2010, Certel et al., 2010, Crocker et al., 2010, Busch et al., 2009, Honjo and Furukubo-Tokunaga, 2009, Crocker and Sehgal, 2008, Zhou et al., 2008, Brembs et al., 2007)

Reporter construct used in assay

Progenitors and Descendants

progenitor(s)

descendant(s)

Comments

Stocks (1)

Stocks containing insertion(s) of this recombinant construct

Bloomington

9313

w^*; P{Tdc2-GAL4.C}2

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (25)

Reported As

Symbol Synonym

P{GAL4-Tdc2.C}

P{Tdc-GAL4.J}

(FlyBase, 1992-)

P{Tdc2-GAL4.C}

(Fernandez-Acosta et al., 2025, Schützler et al., 2019, FlyBase, 1996-)

TDC-GAL4

(Boerner and Duch, 2010, Pauls et al., 2010)

TDC2

(Yarali and Gerber, 2010)

TDC2-GAL4

(Bisen et al., 2025, Wilhelm et al., 2022, Matsuo et al., 2016, Vogt et al., 2014, Castellanos et al., 2013, Liu et al., 2012, Hampel et al., 2011, Boerner and Duch, 2010, Sitaraman et al., 2010, Honjo and Furukubo-Tokunaga, 2009)

TDC2-Gal4

(Kim et al., 2017, Liu et al., 2017, Rohwedder et al., 2016, Garaulet et al., 2014, Lacin et al., 2014, Schoofs et al., 2014, Han et al., 2011, Kaplan et al., 2008, Schroll et al., 2006)

Tdc-GAL4

(Banerjee et al., 2025, Sareen et al., 2021)

Tdc-Gal4

(Slater et al., 2015, Kahsai and Winther, 2011)

Tdc2 GAL4

(Søvik et al., 2017, Kahsai and Winther, 2011)

Tdc2-GAL4

(Ahrentløv et al., 2025, Bervoets et al., 2025, Ding et al., 2025, Held et al., 2025, Meimoun et al., 2025, Meng et al., 2025, Wu et al., 2025, Lv et al., 2024, Deshpande et al., 2022, Ishii et al., 2022, Kim et al., 2021, Wong et al., 2021, Harrigan et al., 2020, Imura et al., 2020, Pop et al., 2020, Yalgin et al., 2020, Castells-Nobau et al., 2019, Meissner et al., 2019, Koon et al., 2018, Strother et al., 2018, Sethi and Wang, 2017, Watanabe et al., 2017, Freyberg et al., 2016, Jayakumar et al., 2016, Yilmazer et al., 2016, Yu et al., 2016, Shih et al., 2015, Kunst et al., 2014, Lacin et al., 2014, Lin et al., 2014, Selcho et al., 2014, Williams et al., 2014, Williams et al., 2014, Castellanos et al., 2013, Chen et al., 2013, Burke et al., 2012, Henry et al., 2012, Schneider et al., 2012, Chiang et al., 2011, Kahsai and Winther, 2011, Keegan et al., 2011, Crocker et al., 2010, Dankert et al., 2009)

Tdc2-Gal4

(Warnecke et al., 2026, Aughey et al., 2025, Bakshinska et al., 2025, Hu et al., 2025, Kautzmann et al., 2025, Smithson et al., 2025, Aimon et al., 2023, Axelrod et al., 2023, Bazzi et al., 2023, Fedina et al., 2023, Gowda et al., 2023, Titos et al., 2023, Gu et al., 2022, Nakagawa et al., 2022, Zhang et al., 2022, Lee et al., 2020, Palazzo et al., 2020, Rallis et al., 2020, Babski et al., 2019, Chen et al., 2019, Cheng et al., 2019, Gong et al., 2019, Masuzzo et al., 2019, Ni et al., 2019, Sapiro et al., 2019, Bai et al., 2018, Hartenstein et al., 2018, Pauls et al., 2018, Sonn et al., 2018, Valadas et al., 2018, Kurz et al., 2017, Wang et al., 2016, Zhang et al., 2016, Kirkhart and Scott, 2015, Okamoto and Nishimura, 2015, Seidner et al., 2015, Shankar et al., 2015, Wasserman et al., 2015, Andrews et al., 2014, Grygoruk et al., 2014, Hess-Homeier et al., 2014, Rezával et al., 2014, Yuan et al., 2014, Huang et al., 2013, Pech et al., 2013, Koon and Budnik, 2012, Liu et al., 2012, Majumdar et al., 2012, Selcho et al., 2012, Zhou et al., 2012, Chiang et al., 2011, Koon et al., 2011, Stavropoulos and Young, 2011, Nojima et al., 2010, Crocker and Sehgal, 2008, Zhou et al., 2008)

Tdc2-gal4

(Chng et al., 2017, Vömel and Wegener, 2008, Hardie et al., 2007)

Tdc2G4

(Peng et al., 2024)

Tdc2Gal4

(Yang et al., 2025)

dTdc2(tyrosine decarboxylase2)-Gal4

(Certel et al., 2010)

dTdc2-GAL4

(Wu et al., 2013, Lee et al., 2009)

dTdc2-Gal4

(Ruppert et al., 2026, Claßen and Scholz, 2018, Gupta et al., 2016, Kairamkonda and Nongthomba, 2014, Certel et al., 2010, Brembs et al., 2007)

dTdc2.GAL4

(Cole et al., 2005)

tdc-GAL4

(Newquist et al., 2013)

tdc-Gal4

(Kolodziejczyk and Nässel, 2011, Johard et al., 2008)

tdc2-GAL4

(Lyu et al., 2023, Sabandal et al., 2020, Dhiman et al., 2019, Schützler et al., 2019, O'Sullivan et al., 2018, Rubinstein and Wolfner, 2013, Busch and Tanimoto, 2010, Busch et al., 2009)

tdc2-Gal4

(Das Chakraborty et al., 2022, Sherer et al., 2020, Kamimura et al., 2019, Ma et al., 2016, Oh et al., 2014, Zhang et al., 2013, Marella et al., 2012)

tdc2-gal4

(Babski et al., 2024, Gupta et al., 2016)

tyrosine decarboxylase 2 GAL4

(Kahsai and Winther, 2011)

Secondary FlyBase IDs

FBtp0056985
FBtp0021216
FBtp0021220
FBtp0087282

References (160)

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