General Information
Term	hemophagocytic lymphohistiocytosis	ID (Ontology)	DOID:0050120 (Human Disease)
Definition	A lymphatic system disease that is characterized by an expansion of the monocyte-macrophage population and intense hemophagocytosis. It can occur de novo, but more often occurs in the setting of another disorder, usually an infection or a malignancy. A clinical picture of fever, hepatosplenomegaly, lymphadenopathy and peripheral pancytopenia. The morphologic hallmark of this syndrome is the phagocytosis of hematopoietic elements by morphologically normal macrophages.
Also Known As	"haemophagocytic syndrome"
Comment
Links to External Ontologies
	DO.org
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Records annotated with this term OR any of its CHILD TERMS
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General Information

Term

hemophagocytic lymphohistiocytosis

ID (Ontology)

DOID:0050120 (Human Disease)

Definition

A lymphatic system disease that is characterized by an expansion of the monocyte-macrophage population and intense hemophagocytosis. It can occur de novo, but more often occurs in the setting of another disorder, usually an infection or a malignancy. A clinical picture of fever, hepatosplenomegaly, lymphadenopathy and peripheral pancytopenia. The morphologic hallmark of this syndrome is the phagocytosis of hematopoietic elements by morphologically normal macrophages.

Also Known As

"haemophagocytic syndrome"

Comment

Links to External Ontologies

DO.org

Annotations

Records annotated with this term OR any of its CHILD TERMS

Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records

No relevant statements available

  immune system disease
   |__lymphatic system disease
       |__hemophagocytic lymphohistiocytosis  3 rec.
           |__familial hemophagocytic lymphohistiocytosis 1
           |__familial hemophagocytic lymphohistiocytosis 2
           |__familial hemophagocytic lymphohistiocytosis 3 1 rec.
           |__familial hemophagocytic lymphohistiocytosis 4 1 rec.
           |__familial hemophagocytic lymphohistiocytosis 5 1 rec.

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Relationships
Is a	lymphatic system disease
Part of
Synonyms & Secondary IDs
Synonyms
	"haemophagocytic syndrome" EXACT
Secondary IDs

External Crossreferences & Linkouts
	GARD:6589 ICD10CM:D76.1 MESH:D051359 MIM:PS267700 NCI:C34792 ORDO:540 SNOMEDCT_US_2023_03_01:190958003 UMLS_CUI:C0024291

Spanning Tree View Settings

Parents/Children
View Depth

Relationships

Is a

lymphatic system disease

Part of

Synonyms & Secondary IDs

Synonyms

"haemophagocytic syndrome" EXACT

Secondary IDs

External Crossreferences & Linkouts

GARD:6589
ICD10CM:D76.1
MESH:D051359
MIM:PS267700
NCI:C34792
ORDO:540
SNOMEDCT_US_2023_03_01:190958003
UMLS_CUI:C0024291