FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term nonepidermolytic palmoplantar keratoderma ID (Ontology) DOID:0050428 (Human Disease)
Definition A palmoplantar keratosis characterized by a well-demarcated, symmetric keratoderma located_in palms and located_in soles.
Also Known As "diffuse nonepidermolytic palmomplantar keratoderma" ; "NEPPK" ; "Thost-Unna Syndrome" (for all, see Synonyms field below)
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Spanning Tree (Parents/Children)
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  keratosis
   |__palmoplantar keratosis
       |__nonepidermolytic palmoplantar keratoderma  15 rec.
           |__Bothnian type palmoplantar keratoderma 6 rec.
           |__focal nonepidermolytic palmoplantar keratoderma 1 rec.
           |   |__focal nonepidermolytic palmoplantar keratoderma 1
           |   |__focal nonepidermolytic palmoplantar keratoderma 2 1 rec.
           |__focal or diffuse nonepidermolytic palmoplantar keratoderma
           |__KRT1-related nonepidermolytic palmoplantar keratoderma
           |__Nagashima-type palmoplantar keratosis 5 rec.
           |__Naxos disease 2 rec.
           |   |__Carvajal syndrome 1 rec.
           |__palmoplantar keratoderma and woolly hair 1 rec.
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Is a palmoplantar keratosis
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Synonyms
  • "diffuse nonepidermolytic palmomplantar keratoderma" EXACT
    "NEPPK" EXACT OMO:0003012
    "Thost-Unna Syndrome" EXACT
    "tylosis" EXACT
    "Unna-Thost Syndrome" EXACT
Secondary IDs
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MESH:C563422
UMLS_CUI:C1833030