FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term Costello syndrome ID (Ontology) DOID:0050469 (Human Disease)
Definition A RASopathy characterized by craniofacial dysmorphology, cardiac defects, mild mental retardation, and high birth weight followed by a failure to thrive and developmental delays.
Also Known As "Faciocutaneoskeletal Syndrome" ; "FCS SYNDROME"
Comment
Links to External Ontologies
DO.org
Annotations
Records annotated with this term OR any of its CHILD TERMS
Records annotated with this exact term (annotations to child terms are NOT included)
Data Class Field Records
Alleles (FBal)  HUMAN_DISEASE_INTERACTIONS       1
Human Disease Models (FBhh)  DOID       1
show Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
 Full annotation statements 
Relevant FlyBase reports
 Alleles Genes Human Disease Models
 Costello syndrome       1      2      1
 for disease ribbon | Costello syndrome       --       1       --
 model of | Costello syndrome       1      1       --
Spanning Tree (Parents/Children)
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autosomal genetic disease
 |__autosomal dominant disease__
syndrome                        |
 |__RASopathy___________________|
                                Costello syndrome  4 rec.
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Is a autosomal dominant disease
RASopathy
Part of
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Synonyms
  • "Faciocutaneoskeletal Syndrome" EXACT
    "FCS SYNDROME" EXACT
Secondary IDs
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GARD:1550
MESH:D056685
MIM:218040
NCI:C84652
SNOMEDCT_US_2023_03_01:205803001
UMLS_CUI:C0587248