FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term transthyretin amyloidosis ID (Ontology) DOID:0050638 (Human Disease)
Definition An amyloidosis that is characterized by a loss of sensation in the extremities, cardiomyopathy, nephropathy, vitreous opacities, and CNS amyloidosis resulting from abnormal deposits of amyloid protein in the body's organs and tissues and has_material_basis_in autosomal dominant inheritance of mutations in the TTR gene.
Also Known As "Amyloidosis, hereditary, transthyretin-related" ; "ATTR amyloidosis" ; "ATTRm amyloidosis" (for all, see Synonyms field below)
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Records annotated with this term OR any of its CHILD TERMS
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Data Class Field Records
Alleles (FBal)  HUMAN_DISEASE_INTERACTIONS      14
Human Disease Models (FBhh)  DOID       1
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Relevant FlyBase reports
 Alleles Genes Human Disease Models
 transthyretin amyloidosis      14      9      1
 ameliorates | transthyretin amyloidosis       6       --       --
 exacerbates | transthyretin amyloidosis       1       --       --
 for disease ribbon | transthyretin amyloidosis       --       1       --
 model of | transthyretin amyloidosis       7      1       --
Spanning Tree (Parents/Children)
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disease of metabolism
 |__inherited metabolic disorder__
 |__amyloidosis___________________|
autosomal genetic disease         |
 |__autosomal dominant disease____|
thoracic disease                  |
 |__heart disease_________________|
cardiovascular system disease     |
 |__heart disease_________________|
genetic disease                   |
 |__inherited metabolic disorder__|
                                  transthyretin amyloidosis  24 rec.
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Is a autosomal dominant disease
heart disease
inherited metabolic disorder
amyloidosis
Part of
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Synonyms
  • "Amyloidosis, hereditary, transthyretin-related" EXACT
    "ATTR amyloidosis" EXACT
    "ATTRm amyloidosis" EXACT
    "Corino de Andrade's disease" EXACT
    "familial amyloid polyneuropathy" EXACT
    "Familial transthyretin amyloidosis" EXACT
    "paramyloidosis" EXACT
    "transthyretin-related hereditary amyloidosis" EXACT
    "TTR amyloidosis" EXACT
Secondary IDs
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GARD:656
ICD10CM:E85.82
MIM:105210
ORDO:85447