FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
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Term type II complement component 8 deficiency ID (Ontology) DOID:0060302 (Human Disease)
Definition A complement deficiency that is characterized by deficiency of the beta subunit of complement protein 8, which causes increased susceptibility to recurrent bacterial infections, especially to Neisseria meningitidis, and has_material_basis_in autosomal recessive inheritance of mutation in the C8B gene, which produces the beta subunit of complement component 8 important in forming membrane attack complexes.
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  primary immunodeficiency disease
   |__complement deficiency
       |__type II complement component 8 deficiency
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ICD10CM:D84.1
MIM:613789
ORDO:169150