FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term immunodeficiency with hyper-IgM type 4 ID (Ontology) DOID:0060760 (Human Disease)
Definition A hyper IgM syndrome that is characterized by normal or increased serum IgM concentrations associated with low or absent serum IgG, IgA, and IgE concentrations, indicating a defect in the class-switch recombination (CSR) process.
Also Known As "HIGM4" ; "hyper-IgM syndrome type 4"
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  hyperimmunoglobulin syndrome
   |__hyper IgM syndrome
       |__immunodeficiency with hyper-IgM type 4
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Is a hyper IgM syndrome
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Synonyms
  • "HIGM4" EXACT OMO:0003012
    "hyper-IgM syndrome type 4" EXACT
Secondary IDs
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GARD:10580
MESH:C564277
MIM:608184
NCI:C564277
ORDO:101091
UMLS_CUI:C1842413