FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term hereditary spastic paraplegia 4 ID (Ontology) DOID:0110792 (Human Disease)
Definition A hereditary spastic paraplegia that is characterized by slowly progressive muscle weakness and spasticity and has_material_basis_in mutation in the SPAST gene on chromosome 2p22.
Also Known As "autosomal dominant spastic paraplegia 4" ; "autosomal dominant spastic paraplegia type 4" ; "SPG4"
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Data Class Field Records
Alleles (FBal)  HUMAN_DISEASE_INTERACTIONS      10
Human Disease Models (FBhh)  DOID       1
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Relevant FlyBase reports
 Alleles Genes Human Disease Models
 hereditary spastic paraplegia 4      10      2      1
 ameliorates | hereditary spastic paraplegia 4       6       --       --
 exacerbates | hereditary spastic paraplegia 4       1       --       --
 for disease ribbon | hereditary spastic paraplegia 4       --       1       --
 model of | hereditary spastic paraplegia 4       3      1       --
Spanning Tree (Parents/Children)
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autosomal genetic disease
 |__autosomal dominant disease_____
paraplegia                         |
 |__hereditary spastic paraplegia__|
                                   hereditary spastic paraplegia 4  13 rec.
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Is a autosomal dominant disease
hereditary spastic paraplegia
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Synonyms
  • "autosomal dominant spastic paraplegia 4" EXACT
    "autosomal dominant spastic paraplegia type 4" EXACT
    "SPG4" EXACT OMO:0003012
Secondary IDs
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ICD10CM:G11.4
MIM:182601
ORDO:100985