FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term leukocyte adhesion deficiency 3 ID (Ontology) DOID:0110912 (Human Disease)
Definition A leukocyte adhesion deficiency that is characterized by a defect in beta integrins 1, 2, and 3; which impairs the integrin activation cascade and has_material_basis_in mutation in FERMT3 gene on chromosome 11q12.
Also Known As "IADD" ; "integrin activation deficiency disease" ; "LAD1 variant" (for all, see Synonyms field below)
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 Genes
 leukocyte adhesion deficiency 3       2
 for disease ribbon | leukocyte adhesion deficiency 3       2
 model of | leukocyte adhesion deficiency 3       2
Spanning Tree (Parents/Children)
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autosomal recessive disease__________________
combined T cell and B cell immunodeficiency__|
leukocyte disease____________________________|
                                             leukocyte adhesion deficiency
                                              |__leukocyte adhesion deficiency 3  2 rec.
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Is a leukocyte adhesion deficiency
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Synonyms
  • "IADD" EXACT OMO:0003012
    "integrin activation deficiency disease" EXACT
    "LAD1 variant" EXACT
    "LAD1V" EXACT OMO:0003012
    "LAD3" EXACT OMO:0003012
    "leukocyte adhesion deficiency 1 variant" EXACT
    "leukocyte adhesion deficiency type III" EXACT
Secondary IDs
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MIM:612840
ORDO:99844