FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term X-Linked immunodeficiency 74 ID (Ontology) DOID:0112063 (Human Disease)
Definition A T cell deficiency characterized by severe respiratory insufficiency in response to infection with the COVID19 coronavirus and impaired signaling through the TLR7 pathway that has_material_basis_in hemizygous mutation in the TLR7 gene on chromosome Xp22.2.
Also Known As "IMD74" ; "respiratory insufficiency due to SARS-CoV-2 viral infection" ; "TLR7 deficiency" (for all, see Synonyms field below)
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 Genes
 X-Linked immunodeficiency 74       8
 for disease ribbon | X-Linked immunodeficiency 74       8
 model of | X-Linked immunodeficiency 74       8
Spanning Tree (Parents/Children)
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X-linked monogenic disease
 |__X-linked recessive disease____
primary immunodeficiency disease  |
 |__T cell deficiency_____________|
                                  X-Linked immunodeficiency 74  8 rec.
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Is a X-linked recessive disease
T cell deficiency
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Synonyms
  • "IMD74" EXACT OMO:0003012
    "respiratory insufficiency due to SARS-CoV-2 viral infection" EXACT
    "TLR7 deficiency" EXACT
    "X-linked immunodeficiency 74,COVID-19-related" EXACT
Secondary IDs
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MIM:301051