FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term hereditary spastic paraplegia 81 ID (Ontology) DOID:0112349 (Human Disease)
Definition A hereditary spastic paraplegia characterized by onset in infancy, delayed motor development, progressive spasticity, and other neurologic impairments that has_material_basis_in homozygous or compound heterozygous mutation in the SELENOI gene on chromosome 2p23.3.
Also Known As "autosomal recessive complex spastic paraplegia due to Kennedy pathway dysfunction" ; "autosomal recessive complex SPG due to Kennedy pathway dysfunction" ; "spastic paraplegia 81 autosomal recessive" (for all, see Synonyms field below)
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 Genes
 hereditary spastic paraplegia 81       2
 for disease ribbon | hereditary spastic paraplegia 81       2
 model of | hereditary spastic paraplegia 81       2
Spanning Tree (Parents/Children)
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autosomal genetic disease
 |__autosomal recessive disease____
paraplegia                         |
 |__hereditary spastic paraplegia__|
                                   hereditary spastic paraplegia 81  2 rec.
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Is a autosomal recessive disease
hereditary spastic paraplegia
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Synonyms
  • "autosomal recessive complex spastic paraplegia due to Kennedy pathway dysfunction" EXACT
    "autosomal recessive complex SPG due to Kennedy pathway dysfunction" EXACT
    "spastic paraplegia 81 autosomal recessive" EXACT
    "SPG81" EXACT OMO:0003012
Secondary IDs
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MIM:618768
ORDO:506353