FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term Alzheimer's disease ID (Ontology) DOID:10652 (Human Disease)
Definition A tauopathy that is characterized by memory lapses, confusion, emotional instability and progressive loss of mental ability and results in progressive memory loss, impaired thinking, disorientation, and changes in personality and mood starting and leads in advanced cases to a profound decline in cognitive and physical functioning and is marked histologically by the degeneration of brain neurons especially in the cerebral cortex and by the presence of neurofibrillary tangles and plaques containing beta-amyloid." [url:http\://en.wikipedia.org/wiki/Alzheimer%27s_disease, url:http\://www.merriam-webster.com/medical/alzheimer%27s%20disease, url:http\://www.nia.nih.gov/alzheimers/publication/alzheimers-disease-fact-sheet] {comment="ls:IEDB"}
Also Known As "Alzheimer disease" ; "Alzheimers dementia"
Comment
Links to External Ontologies
DO.org
Annotations
Records annotated with this term OR any of its CHILD TERMS
Records annotated with this exact term (annotations to child terms are NOT included)
Data Class Field Records
Alleles (FBal)  HUMAN_DISEASE_INTERACTIONS     276
Human Disease Models (FBhh)  DOID      10
show Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
 Full annotation statements 
Relevant FlyBase reports
 Alleles Genes Human Disease Models
 Alzheimer's disease     290    139     10
 ameliorates | Alzheimer's disease     112       --       --
 exacerbates | Alzheimer's disease      69       --       --
 model of | Alzheimer's disease     111       --       --
 DOES NOT ameliorate | Alzheimer's disease       4       --       --
 DOES NOT exacerbate | Alzheimer's disease       1       --       --
 DOES NOT model | Alzheimer's disease       3       --       --
Spanning Tree (Parents/Children)
Only view relationship:
  neurodegenerative disease
   |__tauopathy
       |__Alzheimer's disease  957 rec.
           |__Alzheimer's disease 1 588 rec.
           |__Alzheimer's disease 2 9 rec.
           |__Alzheimer's disease 3 8 rec.
           |__Alzheimer's disease 4 3 rec.
           |__Alzheimer's disease 5
           |__Alzheimer's disease 6
           |__Alzheimer's disease 7
           |__Alzheimer's disease 8
           |__Alzheimer's disease 9 1 rec.
           |__Alzheimer's disease 10
           |__Alzheimer's disease 11
           |__Alzheimer's disease 12
           |__Alzheimer's disease 13
           |__Alzheimer's disease 14
           |__Alzheimer's disease 15
           |__Alzheimer's disease 16
           |__Alzheimer's disease 17
           |__Alzheimer's disease 18 3 rec.
           |__Alzheimer's disease 19
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Is a tauopathy
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Synonyms
  • "Alzheimer disease" EXACT
    "Alzheimers dementia" EXACT
Secondary IDs
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GARD:10254
ICD10CM:G30
ICD9CM:331.0
KEGG:05010
MESH:D000544
NCI:C2866
SNOMEDCT_US_2023_03_01:73768007
UMLS_CUI:C0002395