FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term neurodegenerative disease ID (Ontology) DOID:1289 (Human Disease)
Definition A central nervous system disease that results in the progressive deterioration of function or structure of neurons.
Also Known As "degenerative disease"
Comment
Links to External Ontologies
DO.org
Annotations
Records annotated with this term OR any of its CHILD TERMS
Records annotated with this exact term (annotations to child terms are NOT included)
Data Class Field Records
Alleles (FBal)  HUMAN_DISEASE_INTERACTIONS     496
Human Disease Models (FBhh)  DOID      32
show Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
 Full annotation statements 
Relevant FlyBase reports
 Alleles Genes Human Disease Models
 neurodegenerative disease     525    291     32
 ameliorates | neurodegenerative disease     205       --       --
 exacerbates | neurodegenerative disease     112       --       --
 model of | neurodegenerative disease     222       --       --
 DOES NOT ameliorate | neurodegenerative disease       2       --       --
 DOES NOT exacerbate | neurodegenerative disease       1       --       --
 DOES NOT model | neurodegenerative disease       9       --       --
Spanning Tree (Parents/Children)
Only view relationship:
  nervous system disease
   |__central nervous system disease
       |__neurodegenerative disease  7184 rec.
           |__agenesis of the corpus callosum with peripheral neuropathy 1 rec.
           |__amyotrophic lateral sclerosis-parkinsonism/dementia complex 1 1 rec.
           |__childhood-onset neurodegeneration with brain atrophy 4 rec.
           |__familial encephalopathy with neuroserpin inclusion bodies 19 rec.
           |__hereditary ataxia 1254 rec.
           |   |__autosomal dominant sensory ataxia 1
           |   |__cerebellar ataxia(+) 1092 rec.
           |   |__episodic ataxia(+) 28 rec.
           |   |__spastic ataxia(+) 10 rec.
           |   |__X-linked hereditary ataxia(+) 130 rec.
           |__Huntington's disease 1037 rec.
           |__Huntington's disease-like 2 5 rec.
           |__infantile cerebellar-retinal degeneration 4 rec.
           |__motor neuron disease 2123 rec.
           |   |__amyotrophic lateral sclerosis(+) 1903 rec.
           |   |__anterior horn cell disease
           |   |__lateral sclerosis
           |   |__motor neuritis(+)
           |   |__multisystem proteinopathy
           |   |__nonparalytic poliomyelitis
           |   |__progressive bulbar palsy(+) 1 rec.
           |   |__progressive muscular atrophy
           |   |__scapuloperoneal spinal muscular atrophy 3 rec.
           |   |__spinal muscular atrophy(+) 236 rec.
           |__myoclonic cerebellar dyssynergia
           |__neuroacanthocytosis 5 rec.
           |   |__choreaacanthocytosis 5 rec.
           |   |__McLeod syndrome
           |__neurodegeneration with ataxia, dystonia, and gaze palsy, childhood-onset 4 rec.
           |__neurodegeneration with brain iron accumulation 48 rec.
           |   |__neurodegeneration with brain iron accumulation 2a 8 rec.
           |   |__neurodegeneration with brain iron accumulation 2b 3 rec.
           |   |__neurodegeneration with brain iron accumulation 3 3 rec.
           |   |__neurodegeneration with brain iron accumulation 4 10 rec.
           |   |__neurodegeneration with brain iron accumulation 5 1 rec.
           |   |__neurodegeneration with brain iron accumulation 6 3 rec.
           |   |__pantothenate kinase-associated neurodegeneration 14 rec.
           |__neurodevelopmental disorder with regression, abnormal movements, loss of speech, and seizures 22 rec.
           |__neuronal intranuclear inclusion disease 7 rec.
           |__olivopontocerebellar atrophy 66 rec.
           |__plexopathy
           |__pontocerebellar hypoplasia 42 rec.
           |   |__pontocerebellar hypoplasia type 1(+) 14 rec.
           |   |__pontocerebellar hypoplasia type 2(+) 5 rec.
           |   |__pontocerebellar hypoplasia type 3
           |   |__pontocerebellar hypoplasia type 4 7 rec.
           |   |__pontocerebellar hypoplasia type 5 1 rec.
           |   |__pontocerebellar hypoplasia type 6 1 rec.
           |   |__pontocerebellar hypoplasia type 7
           |   |__pontocerebellar hypoplasia type 8 1 rec.
           |   |__pontocerebellar hypoplasia type 9 1 rec.
           |   |__pontocerebellar hypoplasia type 10 6 rec.
           |   |__pontocerebellar hypoplasia type 11 1 rec.
           |   |__pontocerebellar hypoplasia type 12 1 rec.
           |   |__pontocerebellar hypoplasia type 13 1 rec.
           |   |__pontocerebellar hypoplasia type 14 1 rec.
           |   |__pontocerebellar hypoplasia type 15 1 rec.
           |   |__pontocerebellar hypoplasia type 16 2 rec.
           |__primary cerebellar degeneration
           |__secondary Parkinson disease
           |   |__postencephalitic Parkinson disease
           |__SPOAN syndrome 1 rec.
           |__stress-induced childhood-onset neurodegeneration with variable ataxia and seizures 3 rec.
           |__synucleinopathy 1223 rec.
           |   |__multiple system atrophy(+) 4 rec.
           |   |__Parkinson's disease(+) 1205 rec.
           |__tauopathy 2016 rec.
               |__Alzheimer's disease(+) 957 rec.
               |__chronic traumatic encephalopathy
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Synonyms
  • "degenerative disease" EXACT
Secondary IDs
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ICD10CM:G31.9
MESH:D019636
NCI:C27090
SNOMEDCT_US_2023_03_01:362975008
UMLS_CUI:C0524851
UMLS_CUI:C1285162