FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term motor neuron disease ID (Ontology) DOID:231 (Human Disease)
Definition A neurodegenerative disease that is located_in the motor neurons.
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DO.org
Annotations
Records annotated with this term OR any of its CHILD TERMS
Records annotated with this exact term (annotations to child terms are NOT included)
Data Class Field Records
Alleles (FBal)  HUMAN_DISEASE_INTERACTIONS      17
Human Disease Models (FBhh)  DOID       3
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Relevant FlyBase reports
 Alleles Genes Human Disease Models
 motor neuron disease      18     11      3
 ameliorates | brain ischemia       6       --       --
 ameliorates | motor neuron disease       7       --       --
 exacerbates | brain ischemia       1       --       --
 exacerbates | motor neuron disease       1       --       --
 model of | brain ischemia       1       --       --
 model of | motor neuron disease      11       --       --
Spanning Tree (Parents/Children)
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  central nervous system disease
   |__neurodegenerative disease
       |__motor neuron disease  2123 rec.
           |__amyotrophic lateral sclerosis 1903 rec.
           |   |__amyotrophic lateral sclerosis type 1 40 rec.
           |   |__amyotrophic lateral sclerosis type 2 12 rec.
           |   |__amyotrophic lateral sclerosis type 3
           |   |__amyotrophic lateral sclerosis type 4 7 rec.
           |   |__amyotrophic lateral sclerosis type 5 1 rec.
           |   |__amyotrophic lateral sclerosis type 6 247 rec.
           |   |__amyotrophic lateral sclerosis type 7
           |   |__amyotrophic lateral sclerosis type 8 276 rec.
           |   |__amyotrophic lateral sclerosis type 9 2 rec.
           |   |__amyotrophic lateral sclerosis type 10 507 rec.
           |   |__amyotrophic lateral sclerosis type 11 3 rec.
           |   |__amyotrophic lateral sclerosis type 12 1 rec.
           |   |__amyotrophic lateral sclerosis type 13
           |   |__amyotrophic lateral sclerosis type 15 31 rec.
           |   |__amyotrophic lateral sclerosis type 16 7 rec.
           |   |__amyotrophic lateral sclerosis type 18 6 rec.
           |   |__amyotrophic lateral sclerosis type 19 1 rec.
           |   |__amyotrophic lateral sclerosis type 20 5 rec.
           |   |__amyotrophic lateral sclerosis type 21 24 rec.
           |   |__amyotrophic lateral sclerosis type 22 5 rec.
           |   |__amyotrophic lateral sclerosis type 23 7 rec.
           |   |__amyotrophic lateral sclerosis type 24 6 rec.
           |   |__amyotrophic lateral sclerosis type 25 6 rec.
           |   |__amyotrophic lateral sclerosis type 26 3 rec.
           |   |__amyotrophic lateral sclerosis type 28
           |   |__frontotemporal dementia and/or amyotrophic lateral sclerosis 1 599 rec.
           |   |__frontotemporal dementia and/or amyotrophic lateral sclerosis 2 53 rec.
           |   |__frontotemporal dementia and/or amyotrophic lateral sclerosis 3 6 rec.
           |   |__frontotemporal dementia and/or amyotrophic lateral sclerosis 4 10 rec.
           |   |__frontotemporal dementia and/or amyotrophic lateral sclerosis 6 25 rec.
           |   |__frontotemporal dementia and/or amyotrophic lateral sclerosis 7 41 rec.
           |   |__juvenile amyotrophic lateral sclerosis type 27 1 rec.
           |   |__juvenile amyotrophic lateral sclerosis with dementia
           |   |__sporadic amyotrophic lateral sclerosis
           |__anterior horn cell disease
           |__lateral sclerosis
           |__motor neuritis
           |   |__asymmetric motor neuropathy
           |   |__glossopharyngeal motor neuropathy
           |__multisystem proteinopathy
           |__nonparalytic poliomyelitis
           |__progressive bulbar palsy 1 rec.
           |   |__Fazio-Londe disease 1 rec.
           |__progressive muscular atrophy
           |__scapuloperoneal spinal muscular atrophy 3 rec.
           |__spinal muscular atrophy 236 rec.
               |__adult spinal muscular atrophy 2 rec.
               |__autosomal dominant adult-onset proximal spinal muscular atrophy 9 rec.
               |__autosomal dominant distal hereditary motor neuronopathy(+) 38 rec.
               |__autosomal recessive distal hereditary motor neuronopathy(+) 14 rec.
               |__childhood spinal muscular atrophy(+) 98 rec.
               |__Kennedy's disease 56 rec.
               |__spinal muscular atrophy with lower extremity predominant(+) 7 rec.
               |__spinal muscular atrophy with progressive myoclonic epilepsy
               |__spinal muscular atrophy, Jokela type 5 rec.
               |__X-linked distal spinal muscular atrophy 3 2 rec.
               |__X-linked spinal muscular atrophy 2 1 rec.
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ICD10CM:G12.2
ICD9CM:335.2
MESH:D016472
SNOMEDCT_US_2023_03_01:37340000
UMLS_CUI:C0085084