FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term hereditary spastic paraplegia ID (Ontology) DOID:2476 (Human Disease)
Definition A paraplegia that is characterized by progressive stiffness and contraction (spasticity) in the lower limbs.
Also Known As "familial spastic paraplegia" ; "French settlement disease" ; "hereditary spastic paraparesis" (for all, see Synonyms field below)
Comment
Links to External Ontologies
DO.org
Annotations
Records annotated with this term OR any of its CHILD TERMS
Records annotated with this exact term (annotations to child terms are NOT included)
Data Class Field Records
Alleles (FBal)  HUMAN_DISEASE_INTERACTIONS      33
Human Disease Models (FBhh)  DOID       1
show Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
 Full annotation statements 
Relevant FlyBase reports
 Alleles Genes Human Disease Models
 hereditary spastic paraplegia      34     16      1
 ameliorates | hereditary spastic paraplegia       4       --       --
 exacerbates | hereditary spastic paraplegia       2       --       --
 model of | hereditary spastic paraplegia      28       --       --
 DOES NOT model | hereditary spastic paraplegia       1       --       --
Spanning Tree (Parents/Children)
Only view relationship:
  central nervous system disease
   |__paraplegia
       |__hereditary spastic paraplegia  198 rec.
           |__hereditary spastic paraplegia 2 1 rec.
           |__hereditary spastic paraplegia 3A 25 rec.
           |__hereditary spastic paraplegia 4 13 rec.
           |__hereditary spastic paraplegia 5A
           |__hereditary spastic paraplegia 6 1 rec.
           |__hereditary spastic paraplegia 7 3 rec.
           |__hereditary spastic paraplegia 8 1 rec.
           |__hereditary spastic paraplegia 9A 1 rec.
           |__hereditary spastic paraplegia 9B 1 rec.
           |__hereditary spastic paraplegia 10 2 rec.
           |__hereditary spastic paraplegia 11 1 rec.
           |__hereditary spastic paraplegia 12 7 rec.
           |__hereditary spastic paraplegia 13 4 rec.
           |__hereditary spastic paraplegia 14
           |__hereditary spastic paraplegia 15 3 rec.
           |__hereditary spastic paraplegia 16
           |__hereditary spastic paraplegia 17 2 rec.
           |__hereditary spastic paraplegia 18
           |   |__hereditary spastic paraplegia 18A
           |   |__hereditary spastic paraplegia 18B
           |__hereditary spastic paraplegia 19
           |__hereditary spastic paraplegia 23
           |__hereditary spastic paraplegia 24
           |__hereditary spastic paraplegia 25
           |__hereditary spastic paraplegia 26
           |__hereditary spastic paraplegia 27
           |__hereditary spastic paraplegia 28
           |__hereditary spastic paraplegia 29
           |__hereditary spastic paraplegia 30 2 rec.
           |   |__hereditary spastic paraplegia 30A 1 rec.
           |   |__hereditary spastic paraplegia 30B 1 rec.
           |__hereditary spastic paraplegia 31 3 rec.
           |__hereditary spastic paraplegia 32
           |__hereditary spastic paraplegia 33
           |__hereditary spastic paraplegia 34
           |__hereditary spastic paraplegia 35 6 rec.
           |__hereditary spastic paraplegia 36
           |__hereditary spastic paraplegia 37
           |__hereditary spastic paraplegia 38
           |__hereditary spastic paraplegia 39 2 rec.
           |__hereditary spastic paraplegia 41
           |__hereditary spastic paraplegia 42 1 rec.
           |__hereditary spastic paraplegia 43 3 rec.
           |__hereditary spastic paraplegia 44
           |__hereditary spastic paraplegia 45 1 rec.
           |__hereditary spastic paraplegia 46 1 rec.
           |__hereditary spastic paraplegia 47 2 rec.
           |__hereditary spastic paraplegia 48
           |__hereditary spastic paraplegia 49 1 rec.
           |__hereditary spastic paraplegia 50
           |__hereditary spastic paraplegia 51 1 rec.
           |__hereditary spastic paraplegia 52 2 rec.
           |__hereditary spastic paraplegia 53 1 rec.
           |__hereditary spastic paraplegia 54 1 rec.
           |__hereditary spastic paraplegia 55 1 rec.
           |__hereditary spastic paraplegia 56 3 rec.
           |__hereditary spastic paraplegia 57
           |__hereditary spastic paraplegia 61 11 rec.
           |__hereditary spastic paraplegia 62
           |__hereditary spastic paraplegia 63 1 rec.
           |__hereditary spastic paraplegia 64 1 rec.
           |__hereditary spastic paraplegia 70 1 rec.
           |__hereditary spastic paraplegia 72A 1 rec.
           |__hereditary spastic paraplegia 72B 1 rec.
           |__hereditary spastic paraplegia 73 1 rec.
           |__hereditary spastic paraplegia 74 1 rec.
           |__hereditary spastic paraplegia 75
           |__hereditary spastic paraplegia 76 5 rec.
           |__hereditary spastic paraplegia 77 4 rec.
           |__hereditary spastic paraplegia 78 2 rec.
           |__hereditary spastic paraplegia 79A 1 rec.
           |__hereditary spastic paraplegia 79B 1 rec.
           |__hereditary spastic paraplegia 80 1 rec.
           |__hereditary spastic paraplegia 81 2 rec.
           |__hereditary spastic paraplegia 82 1 rec.
           |__hereditary spastic paraplegia 83 1 rec.
           |__hereditary spastic paraplegia 84 1 rec.
           |__hereditary spastic paraplegia 85
           |__hereditary spastic paraplegia 86 1 rec.
           |__hereditary spastic paraplegia 87 1 rec.
           |__hereditary spastic paraplegia 88 2 rec.
           |__hereditary spastic paraplegia 89 3 rec.
           |__hereditary spastic paraplegia 90A 9 rec.
           |__hereditary spastic paraplegia 90B 1 rec.
           |__hereditary spastic paraplegia 91 1 rec.
           |__hereditary spastic paraplegia 92 2 rec.
           |__hereditary spastic paraplegia 93 3 rec.
           |__MASA syndrome 6 rec.
           |__Mast syndrome
           |__spastic paraplegia with deafness
           |__Troyer syndrome 14 rec.
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Synonyms
  • "familial spastic paraplegia" EXACT
    "French settlement disease" EXACT
    "hereditary spastic paraparesis" EXACT
    "Strumpell-Lorrain disease" EXACT
Secondary IDs
hide External Crossreferences & Linkouts
GARD:6637
ICD10CM:G11.4
ICD9CM:334.1
MESH:D015419
MIM:PS303350
NCI:C140267
SNOMEDCT_US_2023_03_01:267692008
UMLS_CUI:C0037773