FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term central nervous system disease ID (Ontology) DOID:331 (Human Disease)
Definition A nervous system disease that affects either the spinal cord (myelopathy) or brain (encephalopathy) of the central nervous system.
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Records annotated with this term OR any of its CHILD TERMS
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Data Class Field Records
Alleles (FBal)  HUMAN_DISEASE_INTERACTIONS      14
Human Disease Models (FBhh)  DOID       8
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 Alleles Genes Human Disease Models
 central nervous system disease      15     13      8
 ameliorates | central nervous system disease       3       --       --
 for disease ribbon | lymphangioleiomyomatosis       --       2       --
 model of | bipolar disorder       2       --       --
 model of | central nervous system disease      11       --       --
 model of | lymphangioleiomyomatosis       --       2       --
 DOES NOT model | central nervous system disease       1       --       --
Spanning Tree (Parents/Children)
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  disease of anatomical entity
   |__nervous system disease
       |__central nervous system disease  8536 rec.
           |__angiostrongyliasis
           |__autoimmune disease of central nervous system
           |   |__autoimmune neuropathy
           |   |__multiple sclerosis(+)
           |   |__neuromyelitis optica
           |__borna disease
           |__brain disease 2616 rec.
           |   |__akinetic mutism
           |   |__alveolar echinococcosis
           |   |__Athabaskan brainstem dysgenesis syndrome 1 rec.
           |   |__basal ganglia disease(+) 7 rec.
           |   |__baylisascariasis
           |   |__brain cancer(+) 474 rec.
           |   |__brain compression
           |   |__brain edema
           |   |__brain small vessel disease(+) 3 rec.
           |   |__central nervous system origin vertigo
           |   |__cerebellar disease(+) 1095 rec.
           |   |__cerebral degeneration(+) 111 rec.
           |   |__cerebral palsy(+) 13 rec.
           |   |__cerebritis
           |   |__cerebrovascular disease(+) 30 rec.
           |   |__complex cortical dysplasia with other brain malformations(+) 23 rec.
           |   |__congenital variant of Rett syndrome 5 rec.
           |   |__cortical dysplasia-focal epilepsy syndrome 3 rec.
           |   |__cystic echinococcosis
           |   |__diabetic encephalopathy
           |   |__Eastern equine encephalitis
           |   |__encephalitis(+)
           |   |__encephalomalacia(+)
           |   |__epilepsy(+) 551 rec.
           |   |__familial febrile seizures(+) 12 rec.
           |   |__frontotemporal dementia(+) 180 rec.
           |   |__granulomatous amebic encephalitis
           |   |__hepatic encephalopathy(+)
           |   |__heterophyiasis
           |   |__homocarnosinosis
           |   |__hypoglycemic coma
           |   |__hypothalamic disease(+)
           |   |__infantile cerebral and cerebellar atrophy with postnatal progressive microcephaly 1 rec.
           |   |__intracranial hypertension(+)
           |   |__intracranial hypotension
           |   |__Japanese encephalitis 2 rec.
           |   |__Joubert syndrome(+) 15 rec.
           |   |__kernicterus
           |   |__La Crosse encephalitis
           |   |__low grade glioma(+)
           |   |__lymphocytic choriomeningitis
           |   |__MASA syndrome 6 rec.
           |   |__migraine(+) 21 rec.
           |   |__movement disease(+) 120 rec.
           |   |__Murray Valley encephalitis
           |   |__neuroschistosomiasis
           |   |__paragonimiasis
           |   |__PEHO syndrome 1 rec.
           |   |__polymicrogyria(+) 3 rec.
           |   |__porencephaly
           |   |__prion disease(+) 90 rec.
           |   |__pseudobulbar palsy
           |   |__severe congenital encephalopathy due to MECP2 mutation 2 rec.
           |   |__sparganosis
           |   |__tertiary neurosyphilis(+)
           |   |__thalamic disease
           |   |__toxocariasis
           |   |__traumatic brain injury 1 rec.
           |   |__Wernicke encephalopathy
           |   |__West Nile encephalitis(+)
           |   |__Western equine encephalitis
           |__central nervous system benign neoplasm 1 rec.
           |   |__arteriovenous malformations of the brain 1 rec.
           |   |__benign meningioma
           |   |__brain angioma(+)
           |   |__central nervous system chondroma
           |   |__central nervous system hemangioma
           |   |__central nervous system leiomyoma
           |   |__central nervous system lipoma(+)
           |   |__craniopharyngioma(+)
           |   |__diffuse leptomeningeal glioneuronal tumor
           |   |__dysembryoplastic neuroepithelial tumor
           |   |__epidural spinal canal angiolipoma
           |   |__gangliocytoma
           |   |__ganglioglioma(+)
           |   |__low grade glioma(+)
           |   |__meningeal melanocytoma
           |   |__multinodular and vacuolating neuronal tumor
           |   |__myxoid glioneuronal tumor
           |   |__papillary glioneuronal tumor
           |   |__perineural angioma
           |   |__peripheral nervous system benign neoplasm(+)
           |   |__polymorphous low grade neuroepithelial tumour of the young
           |   |__rosette-forming glioneuronal tumor
           |   |__spinal cord dermoid cyst
           |__central nervous system cancer 532 rec.
           |   |__adult central nervous system choriocarcinoma
           |   |__brain cancer(+) 474 rec.
           |   |__central nervous system germ cell tumor(+)
           |   |__central nervous system hematologic cancer(+)
           |   |__central nervous system melanocytic neoplasm(+)
           |   |__central nervous system mesenchymal non-meningothelial tumor(+)
           |   |__central nervous system rhabdomyosarcoma
           |   |__central nervous system sarcoma(+)
           |   |__cranial nerve malignant neoplasm(+)
           |   |__malignant astrocytoma(+) 27 rec.
           |   |__meningioma(+)
           |   |__spinal cancer(+)
           |__central nervous system tuberculosis
           |__central nervous system vasculitis
           |   |__temporal arteritis
           |__coenurosis
           |__cysticercosis
           |__demyelinating disease
           |   |__central pontine myelinolysis
           |   |__multiple sclerosis(+)
           |__encephalomyelitis
           |   |__acute disseminated encephalomyelitis(+)
           |__epidural abscess
           |__hemiplegia 2 rec.
           |   |__alternating hemiplegia of childhood 2 rec.
           |__high pressure neurological syndrome
           |__intracranial abscess
           |__meningitis
           |   |__arachnoiditis
           |   |__aseptic meningitis
           |   |__bacterial meningitis(+)
           |   |__chronic meningitis(+)
           |   |__fungal meningitis(+)
           |   |__viral meningitis
           |__meningoencephalitis
           |__neurodegenerative disease 7184 rec.
           |   |__agenesis of the corpus callosum with peripheral neuropathy 1 rec.
           |   |__amyotrophic lateral sclerosis-parkinsonism/dementia complex 1 1 rec.
           |   |__childhood-onset neurodegeneration with brain atrophy 4 rec.
           |   |__familial encephalopathy with neuroserpin inclusion bodies 19 rec.
           |   |__hereditary ataxia(+) 1254 rec.
           |   |__Huntington's disease 1037 rec.
           |   |__Huntington's disease-like 2 5 rec.
           |   |__infantile cerebellar-retinal degeneration 4 rec.
           |   |__motor neuron disease(+) 2123 rec.
           |   |__myoclonic cerebellar dyssynergia
           |   |__neuroacanthocytosis(+) 5 rec.
           |   |__neurodegeneration with ataxia, dystonia, and gaze palsy, childhood-onset 4 rec.
           |   |__neurodegeneration with brain iron accumulation(+) 48 rec.
           |   |__neurodevelopmental disorder with regression, abnormal movements, loss of speech, and seizures 22 rec.
           |   |__neuronal intranuclear inclusion disease 7 rec.
           |   |__olivopontocerebellar atrophy 66 rec.
           |   |__plexopathy
           |   |__pontocerebellar hypoplasia(+) 42 rec.
           |   |__primary cerebellar degeneration
           |   |__secondary Parkinson disease(+)
           |   |__SPOAN syndrome 1 rec.
           |   |__stress-induced childhood-onset neurodegeneration with variable ataxia and seizures 3 rec.
           |   |__synucleinopathy(+) 1223 rec.
           |   |__tauopathy(+) 2016 rec.
           |__neuronitis
           |__paralytic poliomyelitis
           |   |__bulbar polio
           |   |__bulbospinal polio
           |   |__spinal polio
           |__paraplegia 198 rec.
           |   |__Brown-Sequard syndrome
           |   |__hereditary spastic paraplegia(+) 198 rec.
           |__primary amebic meningoencephalitis
           |   |__granulomatous amebic encephalitis
           |__quadriplegia
           |__restless legs syndrome 6 rec.
           |__spinal cord disease
           |   |__baylisascariasis
           |   |__epidural spinal canal angiolipoma
           |   |__HTLV-1-associated myelopathy/tropical spastic paraparesis
           |   |__low grade glioma(+)
           |   |__myelitis(+)
           |   |__myelomeningocele
           |   |__neuromyelitis optica
           |   |__neuroschistosomiasis
           |   |__spinal cancer(+)
           |   |__spinal cord dermoid cyst
           |   |__spinal cord lipoma
           |   |__spinal polio
           |   |__syringomyelia
           |   |__tertiary neurosyphilis(+)
           |   |__tethered spinal cord syndrome
           |   |__vascular myelopathy
           |__strongyloidiasis
           |__subdural empyema
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ICD10CM:G96.9
MESH:D002493
NCI:C2934
SNOMEDCT_US_2023_03_01:267144009
UMLS_CUI:C0007682