FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term Alexander disease ID (Ontology) DOID:4252 (Human Disease)
Definition A leukodystrophy that is characterized by the destruction of white matter and the formation of Rosenthal fibers consisting of abnormal clumps of protein that accumulate in astrocytes.
Also Known As "Alexander's disease"
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DO.org
Annotations
Records annotated with this term OR any of its CHILD TERMS
Records annotated with this exact term (annotations to child terms are NOT included)
Data Class Field Records
Alleles (FBal)  HUMAN_DISEASE_INTERACTIONS      22
Human Disease Models (FBhh)  DOID       1
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Relevant FlyBase reports
 Alleles Genes Human Disease Models
 Alexander disease      23     15      1
 ameliorates | Alexander disease      17       --       --
 exacerbates | Alexander disease       4       --       --
 model of | Alexander disease       2       --       --
Spanning Tree (Parents/Children)
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autosomal genetic disease
 |__autosomal dominant disease__
cerebral degeneration           |
 |__leukodystrophy______________|
                                Alexander disease  39 rec.
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Is a autosomal dominant disease
leukodystrophy
Part of
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Synonyms
  • "Alexander's disease" EXACT
Secondary IDs
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GARD:5774
MESH:D038261
MIM:203450
NCI:C84545
SNOMEDCT_US_2023_03_01:81854007
UMLS_CUI:C0270726